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• W2045608725 abstract "Although ribosomal RNAs (rRNAs) comprise the bulk of the ribosome and carry out its main functions, ribosomal proteins also appear to play important structural and functional roles. Many ribosomal proteins contain long, nonglobular domains that extend deep into the rRNA cores. In eukaryotes and Archaea, ribosomal protein L3 contains two such extended domains tethered to a common globular hub, thus providing an excellent model to address basic questions relating to ribosomal protein structure/function relationships. Previous work in our laboratory identified the central 'W-finger' extension of yeast L3 in helping to coordinate ribosomal functions. New studies on the 'N-terminal' extension in yeast suggest that it works with the W-finger to coordinate opening and closing of the corridor through which the 3' end of aa-tRNA moves during the process of accommodation. Additionally, the effect of one of the L3 N-terminal extension mutants on the interaction between C75 of the aa-tRNA and G2921 (Escherichia coli G2553) of 25S rRNA provides the first evidence of the effect of a ribosomal protein on aa-tRNA positioning and peptidyltransfer, possibly through the induced fit model. A model is presented describing how all three domains of L3 may function together as a 'rocker switch' to coordinate the stepwise processes of translation elongation." @default.
• W2045608725 created "2016-06-24" @default.
• W2045608725 creator A5065393739 @default.
• W2045608725 creator A5066267623 @default.
• W2045608725 date "2008-10-02" @default.
• W2045608725 modified "2023-09-27" @default.
• W2045608725 title "Ribosomal protein L3 functions as a ‘rocker switch’ to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea" @default.
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• W2045608725 doi "https://doi.org/10.1093/nar/gkn642" @default.
• W2045608725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2577335" @default.
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