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• W2045609318 abstract "A common dietary component that some people even take as a supplement is converted by the gut microbiota to harmful metabolites linked to heart disease. This finding has cautionary implications. See Article p.57 Stanley Hazen and colleagues show that gut flora can influence cardiovascular disease by metabolizing a dietary phospholipid. A targeted metabolomics approach was used to identify plasma metabolites whose levels predict future risk for experiencing a non-fatal heart attack, stroke or death in subjects undergoing cardiac evaluation. Plasma levels of three metabolites of dietary phosphatidylcholine — choline, betaine and trimethylamine N-oxide (TMAO) — are associated with increased risk of cardiovascular disease. The gut flora is known to have a role in TMAO formation from choline. In addition, experiments in atherosclerosis-prone mice show that dietary choline enhances macrophage foam-cell formation and lesion formation — but not if the gut flora is depleted with antibiotics. This work suggests new diagnostic and therapeutic approaches for atherosclerotic heart disease." @default.
• W2045609318 created "2016-06-24" @default.
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• W2045609318 date "2011-04-01" @default.
• W2045609318 modified "2023-10-03" @default.
• W2045609318 title "The diet–microbe morbid union" @default.
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• W2045609318 doi "https://doi.org/10.1038/472040a" @default.
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