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- W2045609705 abstract "The effects of nitric oxide‐releasing compounds on Dictyostelium discoideum cell development and guanylyl cyclase activity were studied. The addition of SNP (sodium nitroprusside) or SIN‐1 (3‐morpholino‐syndnonimine) to starved cells inhibited their differentiation and aggregation in a concentration‐dependent manner. In contrast to mammalian systems, SNP did not significantly affect guanylyl cyclase activity in cell lysates of D. discoideum nor did it stimulate cGMP production in intact cells. The results suggest that the inhibitory effects of NO on D. discoideum cell aggregation are through a mechanism independent of an effect on guanylyl cyclase activity." @default.
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- W2045609705 date "1992-12-07" @default.
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- W2045609705 title "Nitric oxide‐releasing compounds inhibit <i>Dictyostelium discoideum</i> aggregation without altering cGMP production" @default.
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- W2045609705 doi "https://doi.org/10.1016/0014-5793(92)81459-y" @default.
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