FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045621704> ?p ?o ?g. }

• W2045621704 abstract "Four new molecular entities, N-ethyl-1,4-benzoxazine (MC1), 1-ethyl-6-hydroxymethyl-1,2,3,4-tetrahydroquinoline (MC2), (R,S)-1-ethyl-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (MC3), and 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline MC4, based on the primary pharmacophore 1-ethyl-1,2,3,4-tetrahydroquinoline, were synthesized and tested for their physicochemical properties and pharmacological activities. The ocular hypotensive action was measured as percent intraocular pressure (%IOP) reduction, following topical administration in rabbit IOP recovery rate assay in vivo. The results were 4.8%, 14%, 4.5%, and 33% reduction for MC1, MC2, MC3, and MC4, respectively, with MC4 being the only statistically significant potent compound. The physicochemical properties such as solubility, distribution coefficient, and pKa were then determined in order to explain their pharmacological activities or lack thereof. MC4, the active compound, showed the highest solubility in pH 7.4 buffer, and in conjunction with ionization and distribution coefficient values, is expected to easily penetrate through the lipophilic corneal epithelium in comparison with the other compounds. Although the in vivo potency of MC4 can be attributed at least in part to its optimum physicochemical properties, it is important to note that differences in the receptor binding/potency, pharmacokinetic properties, and transporter interaction can also play a role in explaining the biological activity." @default.
• W2045621704 created "2016-06-24" @default.
• W2045621704 creator A5057798851 @default.
• W2045621704 creator A5058719644 @default.
• W2045621704 date "2011-12-01" @default.
• W2045621704 modified "2023-09-23" @default.
• W2045621704 title "Ocular Hypotensive Action of a Novel Tetrahydroquinoline Analog in Rabbit: Physicochemical Evaluation" @default.
• W2045621704 cites W1511884142 @default.
• W2045621704 cites W1537867938 @default.
• W2045621704 cites W1571746100 @default.
• W2045621704 cites W182201849 @default.
• W2045621704 cites W1962217919 @default.
• W2045621704 cites W1978534407 @default.
• W2045621704 cites W1985933245 @default.
• W2045621704 cites W1989594292 @default.
• W2045621704 cites W1992927986 @default.
• W2045621704 cites W1996965420 @default.
• W2045621704 cites W2003593651 @default.
• W2045621704 cites W2005441136 @default.
• W2045621704 cites W2007478842 @default.
• W2045621704 cites W2010180199 @default.
• W2045621704 cites W2010832142 @default.
• W2045621704 cites W2016735163 @default.
• W2045621704 cites W2030357956 @default.
• W2045621704 cites W2034742653 @default.
• W2045621704 cites W2035174404 @default.
• W2045621704 cites W2042274420 @default.
• W2045621704 cites W2047189949 @default.
• W2045621704 cites W2049462370 @default.
• W2045621704 cites W2052093626 @default.
• W2045621704 cites W2057312640 @default.
• W2045621704 cites W2060123451 @default.
• W2045621704 cites W2062101624 @default.
• W2045621704 cites W2065246435 @default.
• W2045621704 cites W2067538516 @default.
• W2045621704 cites W2089074728 @default.
• W2045621704 cites W2090203425 @default.
• W2045621704 cites W2095995222 @default.
• W2045621704 cites W2137221550 @default.
• W2045621704 cites W2145192598 @default.
• W2045621704 cites W2336197566 @default.
• W2045621704 cites W603324113 @default.
• W2045621704 cites W2413583198 @default.
• W2045621704 cites W80527318 @default.
• W2045621704 doi "https://doi.org/10.1002/jps.22717" @default.
• W2045621704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21837649" @default.
• W2045621704 hasPublicationYear "2011" @default.
• W2045621704 type Work @default.
• W2045621704 sameAs 2045621704 @default.
• W2045621704 citedByCount "2" @default.
• W2045621704 countsByYear W20456217042012 @default.
• W2045621704 crossrefType "journal-article" @default.
• W2045621704 hasAuthorship W2045621704A5057798851 @default.
• W2045621704 hasAuthorship W2045621704A5058719644 @default.
• W2045621704 hasConcept C112705442 @default.
• W2045621704 hasConcept C118487528 @default.
• W2045621704 hasConcept C150903083 @default.
• W2045621704 hasConcept C155574463 @default.
• W2045621704 hasConcept C178790620 @default.
• W2045621704 hasConcept C185592680 @default.
• W2045621704 hasConcept C202751555 @default.
• W2045621704 hasConcept C207001950 @default.
• W2045621704 hasConcept C2780591741 @default.
• W2045621704 hasConcept C2781092963 @default.
• W2045621704 hasConcept C43617362 @default.
• W2045621704 hasConcept C55493867 @default.
• W2045621704 hasConcept C56173144 @default.
• W2045621704 hasConcept C57992300 @default.
• W2045621704 hasConcept C71240020 @default.
• W2045621704 hasConcept C71924100 @default.
• W2045621704 hasConcept C86803240 @default.
• W2045621704 hasConcept C98274493 @default.
• W2045621704 hasConceptScore W2045621704C112705442 @default.
• W2045621704 hasConceptScore W2045621704C118487528 @default.
• W2045621704 hasConceptScore W2045621704C150903083 @default.
• W2045621704 hasConceptScore W2045621704C155574463 @default.
• W2045621704 hasConceptScore W2045621704C178790620 @default.
• W2045621704 hasConceptScore W2045621704C185592680 @default.
• W2045621704 hasConceptScore W2045621704C202751555 @default.
• W2045621704 hasConceptScore W2045621704C207001950 @default.
• W2045621704 hasConceptScore W2045621704C2780591741 @default.
• W2045621704 hasConceptScore W2045621704C2781092963 @default.
• W2045621704 hasConceptScore W2045621704C43617362 @default.
• W2045621704 hasConceptScore W2045621704C55493867 @default.
• W2045621704 hasConceptScore W2045621704C56173144 @default.
• W2045621704 hasConceptScore W2045621704C57992300 @default.
• W2045621704 hasConceptScore W2045621704C71240020 @default.
• W2045621704 hasConceptScore W2045621704C71924100 @default.
• W2045621704 hasConceptScore W2045621704C86803240 @default.
• W2045621704 hasConceptScore W2045621704C98274493 @default.
• W2045621704 hasLocation W20456217041 @default.
• W2045621704 hasLocation W20456217042 @default.
• W2045621704 hasOpenAccess W2045621704 @default.
• W2045621704 hasPrimaryLocation W20456217041 @default.
• W2045621704 hasRelatedWork W1967892728 @default.
• W2045621704 hasRelatedWork W2104838039 @default.
• W2045621704 hasRelatedWork W2234076456 @default.
• W2045621704 hasRelatedWork W2303112427 @default.
• W2045621704 hasRelatedWork W2330325755 @default.
• W2045621704 isParatext "false" @default.

• next