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• W2045621723 abstract "• BM inhibited activation of iNOS, generation of NO and nitrotyrosine in UVB exposure. • BM extract suppressed NF-kB activation and did not affect the activity of total ERK ½. • BM increased ERK 1/2 activity and reduced iNOS and nitrotyrosine in 10d experiment. • Pretreatment with BM extract inhibited proliferation and modulated the apoptosis. Molecular mechanisms concerning the modulation of nitrosative stress, signal transduction and proliferation/apoptosis by a grape seed extract, Burgund Mare variety ( BM ), in SKH-1 mice exposed to UVB, were investigated. The animals were irradiated with single and multiple doses of UVB in 10 consecutive days. In each experiment were used five groups of animals: control, vehicle, UVB irradiated, vehicle + UVB, BM + UVB. The extract was applied topically, 30 min before each UVB exposure, in a dose of 4 mg total polyphenols/cm 2 . BM remarkably inhibited UVB-induced activation of inducible nitric oxide synthase (iNOS) and therefore generation of nitric oxide (NO) and nitrotyrosine, in a UVB single dose regimen. BM also suppressed NF-kB activation by UVB but did not affect the activity of total ERK 1/2. In multiple UVB irradiations, BM increased NO formation and total ERK 1/2 activity and reduced iNOS activity and nitrotyrosine levels, inhibited cell proliferation, diminished p53 and caspase-3 immunoreactivities and increased the percentage of Bcl-2 positive cells. We concluded that BM modulates the apoptotic response of SKH-1 mice skin in UVB irradiation by the inhibition of p53, caspase-3, Bax/Bcl-2 and proliferating cell nuclear antigen expressions, as well as by reducing the activation of iNOS and NF-kB." @default.
• W2045621723 created "2016-06-24" @default.
• W2045621723 creator A5005582422 @default.
• W2045621723 creator A5016041494 @default.
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• W2045621723 creator A5023852822 @default.
• W2045621723 creator A5042548956 @default.
• W2045621723 creator A5061399352 @default.
• W2045621723 date "2013-07-01" @default.
• W2045621723 modified "2023-10-18" @default.
• W2045621723 title "Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice" @default.
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• W2045621723 doi "https://doi.org/10.1016/j.fct.2013.03.031" @default.
• W2045621723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23567245" @default.
• W2045621723 hasPublicationYear "2013" @default.
• W2045621723 type Work @default.

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