FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045623677> ?p ?o ?g. }

• W2045623677 endingPage "1384" @default.
• W2045623677 startingPage "1378" @default.
• W2045623677 abstract "An important mechanism whereby growth factors stimulate vascular smooth muscle cell proliferation is by increasing insulin-like growth factor (IGF)-I receptor binding. To characterize the mechanisms involved, we studied transcription of the IGF-I receptor gene in rat aortic smooth muscle cells. Angiotensin II (100 nM) and basic fibroblast growth factor (5 ng/ml) caused a marked increase in IGF-I receptor messenger RNA (mRNA) levels, peaking at 3 h (215 +/- 16.8% and 85 +/- 7.4% above control, respectively). Nuclear run-on assays indicated that angiotensin II and fibroblast growth factor stimulated IGF-I receptor gene transcription by 2.1- and 2.5-fold, respectively. Down-regulation of protein kinase C, a serine/threonine kinase that is important in growth factor-activated signal transduction, completely inhibited fibroblast growth factor- but not angiotensin II-mediated up-regulation of IGF-I receptor mRNA. The protein kinase C inhibitors chelerythrine (3 microns), calphostin C (100 nM), and staurosporine (10 nM) also blocked fibroblast growth factor but not angiotensin II induction of IGF-I receptor mRNA. Thus, angiotensin II and fibroblast growth factor transcriptionally regulate the IGF-I receptor gene by protein kinase C-independent and -dependent pathways, respectively. In view of our prior data indicating that IGF-I receptor density is a critical determinant of vascular smooth muscle cell growth, our findings have particular relevance to understanding mechanisms whereby growth factors regulate vascular proliferation in vivo." @default.
• W2045623677 created "2016-06-24" @default.
• W2045623677 creator A5021270107 @default.
• W2045623677 creator A5038380689 @default.
• W2045623677 creator A5058814917 @default.
• W2045623677 date "1996-04-01" @default.
• W2045623677 modified "2023-09-27" @default.
• W2045623677 title "Transcriptional regulation of the insulin-like growth factor-I receptor gene: evidence for protein kinase C-dependent and -independent pathways." @default.
• W2045623677 cites W115477762 @default.
• W2045623677 cites W148785554 @default.
• W2045623677 cites W1505650038 @default.
• W2045623677 cites W1584184269 @default.
• W2045623677 cites W1603860993 @default.
• W2045623677 cites W1824970382 @default.
• W2045623677 cites W1877069809 @default.
• W2045623677 cites W1905490886 @default.
• W2045623677 cites W1944551911 @default.
• W2045623677 cites W1965368707 @default.
• W2045623677 cites W1965675319 @default.
• W2045623677 cites W1970285990 @default.
• W2045623677 cites W1973418379 @default.
• W2045623677 cites W1981670577 @default.
• W2045623677 cites W1983394026 @default.
• W2045623677 cites W1993367266 @default.
• W2045623677 cites W2003632139 @default.
• W2045623677 cites W2024208090 @default.
• W2045623677 cites W2041792559 @default.
• W2045623677 cites W2048180296 @default.
• W2045623677 cites W2048350334 @default.
• W2045623677 cites W2051819610 @default.
• W2045623677 cites W2063992063 @default.
• W2045623677 cites W2064098156 @default.
• W2045623677 cites W2069443830 @default.
• W2045623677 cites W2072514327 @default.
• W2045623677 cites W2075473225 @default.
• W2045623677 cites W2083891157 @default.
• W2045623677 cites W2085547973 @default.
• W2045623677 cites W2100937050 @default.
• W2045623677 cites W2121968060 @default.
• W2045623677 cites W2128746359 @default.
• W2045623677 cites W2145059527 @default.
• W2045623677 cites W2157633223 @default.
• W2045623677 cites W2161763667 @default.
• W2045623677 cites W2175146729 @default.
• W2045623677 doi "https://doi.org/10.1210/endo.137.4.8625914" @default.
• W2045623677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8625914" @default.
• W2045623677 hasPublicationYear "1996" @default.
• W2045623677 type Work @default.
• W2045623677 sameAs 2045623677 @default.
• W2045623677 citedByCount "24" @default.
• W2045623677 countsByYear W20456236772012 @default.
• W2045623677 countsByYear W20456236772014 @default.
• W2045623677 countsByYear W20456236772016 @default.
• W2045623677 countsByYear W20456236772017 @default.
• W2045623677 countsByYear W20456236772021 @default.
• W2045623677 countsByYear W20456236772022 @default.
• W2045623677 crossrefType "journal-article" @default.
• W2045623677 hasAuthorship W2045623677A5021270107 @default.
• W2045623677 hasAuthorship W2045623677A5038380689 @default.
• W2045623677 hasAuthorship W2045623677A5058814917 @default.
• W2045623677 hasBestOaLocation W20456236771 @default.
• W2045623677 hasConcept C126322002 @default.
• W2045623677 hasConcept C134018914 @default.
• W2045623677 hasConcept C144174609 @default.
• W2045623677 hasConcept C170493617 @default.
• W2045623677 hasConcept C2775960820 @default.
• W2045623677 hasConcept C2780689927 @default.
• W2045623677 hasConcept C2908929049 @default.
• W2045623677 hasConcept C50044444 @default.
• W2045623677 hasConcept C55493867 @default.
• W2045623677 hasConcept C66400584 @default.
• W2045623677 hasConcept C71924100 @default.
• W2045623677 hasConcept C74373430 @default.
• W2045623677 hasConcept C82867764 @default.
• W2045623677 hasConcept C84393581 @default.
• W2045623677 hasConcept C86803240 @default.
• W2045623677 hasConcept C95444343 @default.
• W2045623677 hasConceptScore W2045623677C126322002 @default.
• W2045623677 hasConceptScore W2045623677C134018914 @default.
• W2045623677 hasConceptScore W2045623677C144174609 @default.
• W2045623677 hasConceptScore W2045623677C170493617 @default.
• W2045623677 hasConceptScore W2045623677C2775960820 @default.
• W2045623677 hasConceptScore W2045623677C2780689927 @default.
• W2045623677 hasConceptScore W2045623677C2908929049 @default.
• W2045623677 hasConceptScore W2045623677C50044444 @default.
• W2045623677 hasConceptScore W2045623677C55493867 @default.
• W2045623677 hasConceptScore W2045623677C66400584 @default.
• W2045623677 hasConceptScore W2045623677C71924100 @default.
• W2045623677 hasConceptScore W2045623677C74373430 @default.
• W2045623677 hasConceptScore W2045623677C82867764 @default.
• W2045623677 hasConceptScore W2045623677C84393581 @default.
• W2045623677 hasConceptScore W2045623677C86803240 @default.
• W2045623677 hasConceptScore W2045623677C95444343 @default.
• W2045623677 hasIssue "4" @default.
• W2045623677 hasLocation W20456236771 @default.
• W2045623677 hasLocation W20456236772 @default.
• W2045623677 hasOpenAccess W2045623677 @default.
• W2045623677 hasPrimaryLocation W20456236771 @default.

• next