FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045626051> ?p ?o ?g. }

• W2045626051 endingPage "4909" @default.
• W2045626051 startingPage "4903" @default.
• W2045626051 abstract "5,6-Dihydrothymidin-5-yl (1) and 2‘-deoxyuridin-1‘-yl (3) were independently generated in solution under aerobic conditions. The release of superoxide (O2•-) from the respective peroxyl radicals derived from 1 and 3 was determined spectrophotometrically. Competition studies enable one to estimate that the rate constant for elimination of O2•- from the peroxyl radical (4) derived from 3 is ∼1 s-1. This process is competitive with the anticipated rate of trapping of 4 in DNA by glutathione. Relative rate studies indicate that O2•- generation resulting from the formation of 1 under aerobic conditions competes effectively with trapping of the peroxyl radical by Bu3SnH. Superoxide elimination from the peroxyl radical of 1 (2) restores the damaged nucleoside to its unaltered form, implying that this reactive intermediate has a naturally occurring detoxification pathway available to it. However, the freely diffusible superoxide can react further to generate other reactive species capable of damaging nucleic acids, suggesting that the elimination of O2•- from 2 is a potential double-edged sword." @default.
• W2045626051 created "2016-06-24" @default.
• W2045626051 creator A5012792098 @default.
• W2045626051 creator A5044395319 @default.
• W2045626051 creator A5087642554 @default.
• W2045626051 creator A5088493860 @default.
• W2045626051 date "1998-04-29" @default.
• W2045626051 modified "2023-10-16" @default.
• W2045626051 title "Release of Superoxide from Nucleoside Peroxyl Radicals, a Double-Edged Sword?" @default.
• W2045626051 cites W1750690213 @default.
• W2045626051 cites W1940436875 @default.
• W2045626051 cites W1964249238 @default.
• W2045626051 cites W1967836873 @default.
• W2045626051 cites W1967849001 @default.
• W2045626051 cites W1968617443 @default.
• W2045626051 cites W1970274082 @default.
• W2045626051 cites W1973556406 @default.
• W2045626051 cites W1985687573 @default.
• W2045626051 cites W1987822740 @default.
• W2045626051 cites W2004283265 @default.
• W2045626051 cites W2006646523 @default.
• W2045626051 cites W2017626786 @default.
• W2045626051 cites W2022924450 @default.
• W2045626051 cites W2029571275 @default.
• W2045626051 cites W2035201668 @default.
• W2045626051 cites W2036942418 @default.
• W2045626051 cites W2049392271 @default.
• W2045626051 cites W2050844955 @default.
• W2045626051 cites W2054219973 @default.
• W2045626051 cites W2055159418 @default.
• W2045626051 cites W2057187865 @default.
• W2045626051 cites W2070919877 @default.
• W2045626051 cites W2093534711 @default.
• W2045626051 cites W2125492213 @default.
• W2045626051 cites W2168661935 @default.
• W2045626051 cites W2281329705 @default.
• W2045626051 cites W2325993641 @default.
• W2045626051 cites W295367677 @default.
• W2045626051 cites W319489271 @default.
• W2045626051 doi "https://doi.org/10.1021/ja973200s" @default.
• W2045626051 hasPublicationYear "1998" @default.
• W2045626051 type Work @default.
• W2045626051 sameAs 2045626051 @default.
• W2045626051 citedByCount "49" @default.
• W2045626051 countsByYear W20456260512012 @default.
• W2045626051 countsByYear W20456260512013 @default.
• W2045626051 countsByYear W20456260512016 @default.
• W2045626051 countsByYear W20456260512019 @default.
• W2045626051 countsByYear W20456260512021 @default.
• W2045626051 countsByYear W20456260512023 @default.
• W2045626051 crossrefType "journal-article" @default.
• W2045626051 hasAuthorship W2045626051A5012792098 @default.
• W2045626051 hasAuthorship W2045626051A5044395319 @default.
• W2045626051 hasAuthorship W2045626051A5087642554 @default.
• W2045626051 hasAuthorship W2045626051A5088493860 @default.
• W2045626051 hasConcept C121332964 @default.
• W2045626051 hasConcept C139066938 @default.
• W2045626051 hasConcept C148898269 @default.
• W2045626051 hasConcept C181199279 @default.
• W2045626051 hasConcept C185592680 @default.
• W2045626051 hasConcept C24107716 @default.
• W2045626051 hasConcept C2776543447 @default.
• W2045626051 hasConcept C2780795997 @default.
• W2045626051 hasConcept C48349386 @default.
• W2045626051 hasConcept C55493867 @default.
• W2045626051 hasConcept C62520636 @default.
• W2045626051 hasConcept C71240020 @default.
• W2045626051 hasConcept C75473681 @default.
• W2045626051 hasConcept C93391505 @default.
• W2045626051 hasConceptScore W2045626051C121332964 @default.
• W2045626051 hasConceptScore W2045626051C139066938 @default.
• W2045626051 hasConceptScore W2045626051C148898269 @default.
• W2045626051 hasConceptScore W2045626051C181199279 @default.
• W2045626051 hasConceptScore W2045626051C185592680 @default.
• W2045626051 hasConceptScore W2045626051C24107716 @default.
• W2045626051 hasConceptScore W2045626051C2776543447 @default.
• W2045626051 hasConceptScore W2045626051C2780795997 @default.
• W2045626051 hasConceptScore W2045626051C48349386 @default.
• W2045626051 hasConceptScore W2045626051C55493867 @default.
• W2045626051 hasConceptScore W2045626051C62520636 @default.
• W2045626051 hasConceptScore W2045626051C71240020 @default.
• W2045626051 hasConceptScore W2045626051C75473681 @default.
• W2045626051 hasConceptScore W2045626051C93391505 @default.
• W2045626051 hasIssue "20" @default.
• W2045626051 hasLocation W20456260511 @default.
• W2045626051 hasOpenAccess W2045626051 @default.
• W2045626051 hasPrimaryLocation W20456260511 @default.
• W2045626051 hasRelatedWork W1162079594 @default.
• W2045626051 hasRelatedWork W1846758701 @default.
• W2045626051 hasRelatedWork W2003503672 @default.
• W2045626051 hasRelatedWork W2082216829 @default.
• W2045626051 hasRelatedWork W2112001639 @default.
• W2045626051 hasRelatedWork W2408823636 @default.
• W2045626051 hasRelatedWork W2494762210 @default.
• W2045626051 hasRelatedWork W3210494598 @default.
• W2045626051 hasRelatedWork W3634476 @default.
• W2045626051 hasRelatedWork W4244932118 @default.
• W2045626051 hasVolume "120" @default.

• next