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- W2045628878 abstract "WAY 120,491 lowers blood pressure in a number of animal models. Its mechanism of action appears to be the selective opening of K+ channels in vascular smooth muscle cells. The patch clamp technique was used to determine the specific K+ channel affected by WAY 120,491 in isolated tail artery cells of the rat. In the inside-out configuration. WAY 120,491 caused a dose dependent partial reversal of the ATP-induced inactivation of channel activity. Glyburide (10 μM) almost completely inhibited the effect of WAY 120,491. WAY 120,491 had no effect on Ca-activated K+ channels inactivated by the absence of Ca2+. In the whole cell configuration, 10 μM WAY 120,491 increased outward K+ current. 10 μM glyburide completely reversed the increase in current. WAY 120,491 appears to be a relatively specific activator of ATP-sentive K+ channels in vascular smooth muscle." @default.
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- W2045628878 date "1992-11-01" @default.
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- W2045628878 title "WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery" @default.
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- W2045628878 doi "https://doi.org/10.1016/0014-2999(92)94841-i" @default.
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