Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045633232> ?p ?o ?g. }
- W2045633232 endingPage "374" @default.
- W2045633232 startingPage "366" @default.
- W2045633232 abstract "RNA viruses replicate as complex distributions of non-identical but closely related variant genomes termed viral quasispecies. When the error rate during genome replication exceeds a threshold value, the genetic information cannot be maintained and the system enters error catastrophe. This violation of the error threshold results in virus extinction and it is currently being investigated as a new antiviral strategy, based on antiviral activity of some mutagenic agents. Previous studies with the important animal pathogen foot-and-mouth disease virus (FMDV) have shown that FMDV entry into error catastrophe is associated with an increase of complexity (mutation frequency and Shannon entropy) of the mutant spectrum of the quasispecies and that mutated, pre-extinction RNA interferes with the infectivity of standard RNA. Here, we report that despite the increase of complexity, the genomic consensus nucleotide sequence of pre-extinction FMDV RNA remains invariant, and that the fitness of pre-extinction FMDV is at least six-fold lower than the fitness of the parental viral clone, prior to mutagenic treatments. Thus, a low fitness genome ensemble can suppress replication of high fitness virus. Furthermore, the results show that profound genetic modifications associated with fitness decrease of a virus population can take place without any manifestation in the consensus genomic sequence. Thus, increase in mutant spectrum complexity and invariance of the consensus sequence characterizes FMDV extinction through error catastrophe." @default.
- W2045633232 created "2016-06-24" @default.
- W2045633232 creator A5010609839 @default.
- W2045633232 creator A5040474361 @default.
- W2045633232 creator A5053165669 @default.
- W2045633232 creator A5062576020 @default.
- W2045633232 date "2005-10-01" @default.
- W2045633232 modified "2023-10-14" @default.
- W2045633232 title "Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe" @default.
- W2045633232 cites W136988059 @default.
- W2045633232 cites W1464888714 @default.
- W2045633232 cites W1508451045 @default.
- W2045633232 cites W1508613310 @default.
- W2045633232 cites W1526377546 @default.
- W2045633232 cites W1540139062 @default.
- W2045633232 cites W1547087576 @default.
- W2045633232 cites W1547144169 @default.
- W2045633232 cites W1547541251 @default.
- W2045633232 cites W1553547362 @default.
- W2045633232 cites W1585140621 @default.
- W2045633232 cites W1594148812 @default.
- W2045633232 cites W163268065 @default.
- W2045633232 cites W1789669873 @default.
- W2045633232 cites W185131516 @default.
- W2045633232 cites W1964533137 @default.
- W2045633232 cites W1964549964 @default.
- W2045633232 cites W1970321959 @default.
- W2045633232 cites W1976534088 @default.
- W2045633232 cites W1977745444 @default.
- W2045633232 cites W1978146026 @default.
- W2045633232 cites W1978205060 @default.
- W2045633232 cites W1981105411 @default.
- W2045633232 cites W1983134928 @default.
- W2045633232 cites W1991729182 @default.
- W2045633232 cites W1994278598 @default.
- W2045633232 cites W1994399200 @default.
- W2045633232 cites W1994845416 @default.
- W2045633232 cites W1995568450 @default.
- W2045633232 cites W2009478438 @default.
- W2045633232 cites W2010766714 @default.
- W2045633232 cites W2019612933 @default.
- W2045633232 cites W2022291864 @default.
- W2045633232 cites W2030121089 @default.
- W2045633232 cites W2036465650 @default.
- W2045633232 cites W2037212056 @default.
- W2045633232 cites W2037946812 @default.
- W2045633232 cites W2038199465 @default.
- W2045633232 cites W2040525210 @default.
- W2045633232 cites W2040722089 @default.
- W2045633232 cites W2042143187 @default.
- W2045633232 cites W2043553888 @default.
- W2045633232 cites W2045979783 @default.
- W2045633232 cites W2047976861 @default.
- W2045633232 cites W2050024134 @default.
- W2045633232 cites W2055294127 @default.
- W2045633232 cites W2058047903 @default.
- W2045633232 cites W2062290091 @default.
- W2045633232 cites W2064695585 @default.
- W2045633232 cites W2066175267 @default.
- W2045633232 cites W2087895317 @default.
- W2045633232 cites W2089827667 @default.
- W2045633232 cites W2090755397 @default.
- W2045633232 cites W2093031223 @default.
- W2045633232 cites W2096519756 @default.
- W2045633232 cites W2113136473 @default.
- W2045633232 cites W2116597211 @default.
- W2045633232 cites W2119238095 @default.
- W2045633232 cites W2120638695 @default.
- W2045633232 cites W2124690596 @default.
- W2045633232 cites W2130593706 @default.
- W2045633232 cites W2130645941 @default.
- W2045633232 cites W2131382016 @default.
- W2045633232 cites W2143284474 @default.
- W2045633232 cites W2146397496 @default.
- W2045633232 cites W2148195371 @default.
- W2045633232 cites W2165668662 @default.
- W2045633232 cites W2170219825 @default.
- W2045633232 cites W2171820897 @default.
- W2045633232 cites W2188330418 @default.
- W2045633232 cites W283793359 @default.
- W2045633232 cites W2902034448 @default.
- W2045633232 cites W3043402843 @default.
- W2045633232 cites W999725764 @default.
- W2045633232 doi "https://doi.org/10.1016/j.meegid.2005.05.001" @default.
- W2045633232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16002345" @default.
- W2045633232 hasPublicationYear "2005" @default.
- W2045633232 type Work @default.
- W2045633232 sameAs 2045633232 @default.
- W2045633232 citedByCount "45" @default.
- W2045633232 countsByYear W20456332322012 @default.
- W2045633232 countsByYear W20456332322013 @default.
- W2045633232 countsByYear W20456332322014 @default.
- W2045633232 countsByYear W20456332322015 @default.
- W2045633232 countsByYear W20456332322016 @default.
- W2045633232 countsByYear W20456332322017 @default.
- W2045633232 countsByYear W20456332322018 @default.
- W2045633232 countsByYear W20456332322019 @default.
- W2045633232 countsByYear W20456332322020 @default.