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- W2045634511 abstract "Amyotrophic Lateral Sclerosis (ALS) is a progressive and disabling neurodegenerative disorder characterized by upper and lower motor neuron loss, leading to respiratory insufficiency and death after 3-5 years. Riluzole is currently the only FDA approved drug for ALS, but it has only modest effects on survival. The majority of ALS cases are sporadic and probably associated to a multifactorial etiology. With the completion of genome sequencing in humans and model organisms, together with the advent of DNA microarray technology, the transcriptional cascades and networks underlying neurodegeneration in ALS are being elucidated providing new potential pharmacological targets. The main challenge now is the effective screening of the myriad of targets to identify those with the most therapeutic utility. The present review will illustrate how the identification, prioritization and validation of preclinical therapeutics can be achieved through genomic analysis of critical pathways and networks deregulated in ALS pathology." @default.
- W2045634511 created "2016-06-24" @default.
- W2045634511 creator A5013735073 @default.
- W2045634511 creator A5082252143 @default.
- W2045634511 creator A5087738067 @default.
- W2045634511 date "2012-05-01" @default.
- W2045634511 modified "2023-09-24" @default.
- W2045634511 title "Identification of Pharmacological Targets in Amyotrophic Lateral Sclerosis Through Genomic Analysis of Deregulated Genes and Pathways" @default.
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- W2045634511 doi "https://doi.org/10.2174/138920212800793366" @default.
- W2045634511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3394120" @default.