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- W2045637037 abstract "Background: Several epidemiologic studies have examined depression as a risk factor for Alzheimer disease with conflicting results. Most studies relied on self-reported depression, but the agreement between self-reported depression and clinical diagnosis has been reported to be weak, thereby diluting the association. Methods: A population-based cohort in Odense, Denmark, of 3346 persons age 65–84 years was examined at baseline (1992–1994) and after 2 years (1994–1996) and 5 years (1997–1999). History of depression was collected at baseline as self-report. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Persons with a history of depression had an increased risk of Alzheimer disease both at baseline (OR = 1.7; CI = 1.0–2.7) and at follow up (at 2 years, 1.9 [1.0–3.3] and at 5 years, 1.6 [0.9–2.7]). Conclusions: Depression was associated with an increased risk of Alzheimer disease. The odds ratios were lower than generally reported from follow-up studies and are similar to cross-sectional studies." @default.
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- W2045637037 date "2005-03-01" @default.
- W2045637037 modified "2023-10-16" @default.
- W2045637037 title "Depression and the Risk of Alzheimer Disease" @default.
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- W2045637037 doi "https://doi.org/10.1097/01.ede.0000152116.32580.24" @default.
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