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• W2045639473 abstract "In the present study, we measured specific IgE radioallergosorbent test (RAST) levels for house dust, mites, Japanese cedar, kamogaya (Dactylis glomerata) and ragweed antigens in a group of atopic dermatitis (AD) patients and healthy volunteer subjects in our outpatient clinic. We also performed closed patch testing with patch test reagents using the aforementioned antigens prepared from commercially available skin reaction antigens. The dermatologic symptom severity index, duration of disease, total serum IgE, lactate dehydrogenase (LDH) and eosinophil counts were assessed. The relationship between each of these parameters and the intensity of the response to the patch test was then evaluated. The patch test positivity rate increased in proportion with the duration of antigen application, with a maximum of 15.6% for mite antigen and a minimum of 4.7% for cedar antigen by 72 h. There were no antigens showing negative results in any patients. The positivity rate was lower for patch tests applied on highly keratinized areas of skin. The 72 h positive patch test responses were significantly correlated with total serum IgE, LDH, symptom severity index and specific IgE RAST levels. Most positive patch test responses were considered to be possible late phase reactions of the type I allergic response. However, a small number of patients had IgE RAST negative antigens but positive patch tests. These findings suggest the presence of more than one mechanism by which a positive reaction is elicited." @default.
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• W2045639473 date "2001-01-01" @default.
• W2045639473 modified "2023-09-24" @default.
• W2045639473 title "Evaluation of Patch Testing in Atopic Dermatitis Using Commercially Available Environmental Antigens" @default.
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• W2045639473 doi "https://doi.org/10.1046/j.1440-1592.2001.00215.x" @default.
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