Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045640310> ?p ?o ?g. }
- W2045640310 endingPage "687" @default.
- W2045640310 startingPage "670" @default.
- W2045640310 abstract "Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne conidia which are inhaled by humans on a daily basis. When the immune system is compromised (e.g. immunosuppressive therapy prior to organ transplantation) or there is pre-existing pulmonary malfunction (e.g. asthma, cystic fibrosis, TB lesions), A. fumigatus exploits weaknesses in the host defenses which can result in the development of saphrophytic, allergic or invasive aspergillosis. If not effectively eliminated by the innate immune response, conidia germinate and form invasive hyphae which can penetrate pulmonary tissues. The innate immune response to A. fumigatus is stage-specific and various components of the host's defenses are recruited to challenge the different cellular forms of the pathogen. In immunocompetent hosts, anatomical barriers (e.g. the mucociliary elevator) and professional phagocytes such as alveolar macrophages (AM) and neutrophils prevent the development of aspergillosis by inhibiting the growth of conidia and hyphae. The recognition of inhaled conidia by AM leads to the intracellular degradation of the spores and the secretion of proinflammatory mediators which recruit neutrophils to assist in fungal clearance. During the later stages of infection, dendritic cells activate a protective A. fumigatus-specific adaptive immune response which is driven by Th1 CD4(+) T cells." @default.
- W2045640310 created "2016-06-24" @default.
- W2045640310 creator A5043776406 @default.
- W2045640310 creator A5082507527 @default.
- W2045640310 date "2015-04-30" @default.
- W2045640310 modified "2023-10-13" @default.
- W2045640310 title "The innate immune response to<i>Aspergillus fumigatus</i>at the alveolar surface" @default.
- W2045640310 cites W1482128986 @default.
- W2045640310 cites W1483031894 @default.
- W2045640310 cites W1531113262 @default.
- W2045640310 cites W1543145942 @default.
- W2045640310 cites W1562117121 @default.
- W2045640310 cites W1569957341 @default.
- W2045640310 cites W1572272884 @default.
- W2045640310 cites W1572844597 @default.
- W2045640310 cites W1576281382 @default.
- W2045640310 cites W1598141103 @default.
- W2045640310 cites W1649649531 @default.
- W2045640310 cites W1835523535 @default.
- W2045640310 cites W1861035746 @default.
- W2045640310 cites W1874751834 @default.
- W2045640310 cites W1920101996 @default.
- W2045640310 cites W1934547580 @default.
- W2045640310 cites W1969273529 @default.
- W2045640310 cites W1972897007 @default.
- W2045640310 cites W1976620258 @default.
- W2045640310 cites W1979171308 @default.
- W2045640310 cites W1979539511 @default.
- W2045640310 cites W1984722689 @default.
- W2045640310 cites W1985371834 @default.
- W2045640310 cites W1993162037 @default.
- W2045640310 cites W1994710883 @default.
- W2045640310 cites W1995969712 @default.
- W2045640310 cites W1996991255 @default.
- W2045640310 cites W1998735358 @default.
- W2045640310 cites W1999278724 @default.
- W2045640310 cites W2001160691 @default.
- W2045640310 cites W2003581234 @default.
- W2045640310 cites W2004227042 @default.
- W2045640310 cites W2005883179 @default.
- W2045640310 cites W2005998335 @default.
- W2045640310 cites W2013858599 @default.
- W2045640310 cites W2016355432 @default.
- W2045640310 cites W2016385216 @default.
- W2045640310 cites W2017017949 @default.
- W2045640310 cites W2017390384 @default.
- W2045640310 cites W2017825293 @default.
- W2045640310 cites W2019032006 @default.
- W2045640310 cites W2021215684 @default.
- W2045640310 cites W2029631026 @default.
- W2045640310 cites W2032745168 @default.
- W2045640310 cites W2035756538 @default.
- W2045640310 cites W2036903343 @default.
- W2045640310 cites W2038141921 @default.
- W2045640310 cites W2039648381 @default.
- W2045640310 cites W2040177881 @default.
- W2045640310 cites W2040810194 @default.
- W2045640310 cites W2041414113 @default.
- W2045640310 cites W2043161534 @default.
- W2045640310 cites W2043474036 @default.
- W2045640310 cites W2046060908 @default.
- W2045640310 cites W2050177408 @default.
- W2045640310 cites W2052097550 @default.
- W2045640310 cites W2053110161 @default.
- W2045640310 cites W2054429678 @default.
- W2045640310 cites W2054605333 @default.
- W2045640310 cites W2058957540 @default.
- W2045640310 cites W2059442035 @default.
- W2045640310 cites W2060004156 @default.
- W2045640310 cites W2061415739 @default.
- W2045640310 cites W2063668813 @default.
- W2045640310 cites W2065387895 @default.
- W2045640310 cites W2067200826 @default.
- W2045640310 cites W2069970638 @default.
- W2045640310 cites W2072361837 @default.
- W2045640310 cites W2073676586 @default.
- W2045640310 cites W2076551561 @default.
- W2045640310 cites W2076749168 @default.
- W2045640310 cites W2077893603 @default.
- W2045640310 cites W2082791076 @default.
- W2045640310 cites W2084445513 @default.
- W2045640310 cites W2084814184 @default.
- W2045640310 cites W2087114667 @default.
- W2045640310 cites W2087808725 @default.
- W2045640310 cites W2088903425 @default.
- W2045640310 cites W2089135776 @default.
- W2045640310 cites W2094736478 @default.
- W2045640310 cites W2094786750 @default.
- W2045640310 cites W2096728005 @default.
- W2045640310 cites W2096989812 @default.
- W2045640310 cites W2097192281 @default.
- W2045640310 cites W2097252008 @default.
- W2045640310 cites W2098820394 @default.
- W2045640310 cites W2099176294 @default.
- W2045640310 cites W2102373264 @default.
- W2045640310 cites W2103322081 @default.
- W2045640310 cites W2104934425 @default.
- W2045640310 cites W2105683217 @default.