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• W2045641296 startingPage "e1000304" @default.
• W2045641296 abstract "Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages. Nevertheless, the dN/dS measure is often applied to sequences sampled from a single population, the differences among which represent segregating polymorphisms. Here, we study the expected dN/dS ratio for samples drawn from a single population under selection, and we find that in this context, dN/dS is relatively insensitive to the selection coefficient. Moreover, the hallmark signature of positive selection over divergent lineages, dN/dS>1, is violated within a population. For population samples, the relationship between selection and dN/dS does not follow a monotonic function, and so it may be impossible to infer selection pressures from dN/dS. These results have significant implications for the interpretation of dN/dS measurements among population-genetic samples." @default.
• W2045641296 created "2016-06-24" @default.
• W2045641296 creator A5049961627 @default.
• W2045641296 creator A5073702596 @default.
• W2045641296 date "2008-12-12" @default.
• W2045641296 modified "2023-10-17" @default.
• W2045641296 title "The Population Genetics of dN/dS" @default.
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• W2045641296 doi "https://doi.org/10.1371/journal.pgen.1000304" @default.
• W2045641296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2596312" @default.
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