FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045641358> ?p ?o ?g. }

• W2045641358 endingPage "901" @default.
• W2045641358 startingPage "893" @default.
• W2045641358 abstract "Significant differences exist in the production and release of nitric oxide (NO) from human macrophages versus macrophages of mouse origin. Human macrophages have been shown to respond poorly to stimuli that provoke strong inflammatory reactions from mouse macrophages. To address the differences in macrophage function in an animal model, a transgenic mouse was created that contained the entire human NOS2 gene, including the human promoter and all of its exons and introns. The huNOS2 transgenic mouse was then mated to mice lacking a functional NOS2 gene (muNOS2−/− or NOS2 knockout mice) to generate a double transgenic mouse (huNOS2+/0/muNOS2−/−) that expresses a functional human NOS2 gene in place of the mouse NOS2 gene. These double transgenic mice were found to express only human NOS2 mRNA and human iNOS proteins in response to immune stimulation. The production and release of nitric oxide from isolated macrophages from the doubly transgenic mouse also more closely paralleled human responses rather than mouse. Peritoneal macrophages from double transgenic mice generated nanomolar levels of nitrite in response to inflammatory stimuli, while peritoneal macrophages from wild-type mice generated micromolar levels of nitrite in response to the same inflammatory stimuli. Similarly, microglia from the huNOS2+/0/muNOS2−/− mice accumulated nanomolar levels of nitrite following inflammatory stimulation. Reduced nitrite release persisted in spite of normal responsiveness to inflammatory stimulation as measured by tumor necrosis factor alpha and interleukin-6 production and release. These data suggest that the human-specific release of nanomolar levels of nitrite may largely result from differences between the human and mouse NOS2 genes, which may program different degrees of nitric oxide responses to inflammatory signals in humans than in mice." @default.
• W2045641358 created "2016-06-24" @default.
• W2045641358 creator A5000594249 @default.
• W2045641358 creator A5000733461 @default.
• W2045641358 creator A5002100940 @default.
• W2045641358 creator A5026615375 @default.
• W2045641358 creator A5033086401 @default.
• W2045641358 creator A5037870675 @default.
• W2045641358 date "2006-05-01" @default.
• W2045641358 modified "2023-09-25" @default.
• W2045641358 title "Characterization of NO and Cytokine Production in Immune-Activated Microglia and Peritoneal Macrophages Derived from a Mouse Model Expressing the Human NOS2 Gene on a Mouse NOS2 Knockout Background" @default.
• W2045641358 cites W1212704 @default.
• W2045641358 cites W124081177 @default.
• W2045641358 cites W1481263059 @default.
• W2045641358 cites W184726500 @default.
• W2045641358 cites W1965098193 @default.
• W2045641358 cites W1970996854 @default.
• W2045641358 cites W1975366486 @default.
• W2045641358 cites W1979218462 @default.
• W2045641358 cites W1979292955 @default.
• W2045641358 cites W1979407094 @default.
• W2045641358 cites W1980946438 @default.
• W2045641358 cites W1987020637 @default.
• W2045641358 cites W1989219781 @default.
• W2045641358 cites W1998990766 @default.
• W2045641358 cites W2002575458 @default.
• W2045641358 cites W2006318766 @default.
• W2045641358 cites W2009402014 @default.
• W2045641358 cites W2018879423 @default.
• W2045641358 cites W2019489183 @default.
• W2045641358 cites W2021992999 @default.
• W2045641358 cites W2034609016 @default.
• W2045641358 cites W2037535385 @default.
• W2045641358 cites W2043832602 @default.
• W2045641358 cites W2045384882 @default.
• W2045641358 cites W2047557745 @default.
• W2045641358 cites W2051061580 @default.
• W2045641358 cites W2057792332 @default.
• W2045641358 cites W2060980402 @default.
• W2045641358 cites W2066515050 @default.
• W2045641358 cites W2073016013 @default.
• W2045641358 cites W2073134770 @default.
• W2045641358 cites W2074026767 @default.
• W2045641358 cites W2084408440 @default.
• W2045641358 cites W2087042403 @default.
• W2045641358 cites W2090669872 @default.
• W2045641358 cites W2091798202 @default.
• W2045641358 cites W2096505980 @default.
• W2045641358 cites W2100286113 @default.
• W2045641358 cites W2105755732 @default.
• W2045641358 cites W2107277218 @default.
• W2045641358 cites W2109654316 @default.
• W2045641358 cites W2132925738 @default.
• W2045641358 cites W2140458239 @default.
• W2045641358 cites W2145624208 @default.
• W2045641358 cites W2152611825 @default.
• W2045641358 cites W2159069239 @default.
• W2045641358 cites W2169140191 @default.
• W2045641358 cites W2179702494 @default.
• W2045641358 cites W2215459356 @default.
• W2045641358 cites W2270347529 @default.
• W2045641358 cites W2292329478 @default.
• W2045641358 cites W4230793414 @default.
• W2045641358 cites W4236353772 @default.
• W2045641358 cites W4248549364 @default.
• W2045641358 doi "https://doi.org/10.1089/ars.2006.8.893" @default.
• W2045641358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16771679" @default.
• W2045641358 hasPublicationYear "2006" @default.
• W2045641358 type Work @default.
• W2045641358 sameAs 2045641358 @default.
• W2045641358 citedByCount "21" @default.
• W2045641358 countsByYear W20456413582013 @default.
• W2045641358 countsByYear W20456413582014 @default.
• W2045641358 countsByYear W20456413582016 @default.
• W2045641358 countsByYear W20456413582018 @default.
• W2045641358 countsByYear W20456413582019 @default.
• W2045641358 countsByYear W20456413582020 @default.
• W2045641358 countsByYear W20456413582021 @default.
• W2045641358 countsByYear W20456413582022 @default.
• W2045641358 crossrefType "journal-article" @default.
• W2045641358 hasAuthorship W2045641358A5000594249 @default.
• W2045641358 hasAuthorship W2045641358A5000733461 @default.
• W2045641358 hasAuthorship W2045641358A5002100940 @default.
• W2045641358 hasAuthorship W2045641358A5026615375 @default.
• W2045641358 hasAuthorship W2045641358A5033086401 @default.
• W2045641358 hasAuthorship W2045641358A5037870675 @default.
• W2045641358 hasConcept C102230213 @default.
• W2045641358 hasConcept C104317684 @default.
• W2045641358 hasConcept C134018914 @default.
• W2045641358 hasConcept C141035611 @default.
• W2045641358 hasConcept C153911025 @default.
• W2045641358 hasConcept C17991360 @default.
• W2045641358 hasConcept C182704531 @default.
• W2045641358 hasConcept C202751555 @default.
• W2045641358 hasConcept C203014093 @default.
• W2045641358 hasConcept C24998067 @default.
• W2045641358 hasConcept C2776914184 @default.
• W2045641358 hasConcept C2778690821 @default.

• next