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- W2045642295 abstract "Abstract Twenty-two normal subjects received 35 mg rectal diazepam. Plasma levels and sedative effects were measured up to twelve hours after medication. The tests applied were the Trieger dot test (DOT), perceptual speed test (PST), digit symbol substitution test (DSST), continous simple reaction time and subjective assessment of sedation (SAS). Psychomotor performance under influence of the drug was interpolated at the ascending and the descending part of the plasma concentration curve at 400 ng/ml diazepam. Eysenck Personality Questionnaire (EPQ), Spielberger State-Trait Anxiety Inventory (STAI) and Mood Adjective Checklist (MACL) related to individual differences in baseline performance and interpolated scores at the ascending part of the plasma concentration curve. Eysenck's psychoticism dimension and subjective experience of being tired prior to drug administration were the best predictors of amount of drug decrement." @default.
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- W2045642295 date "1993-01-01" @default.
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- W2045642295 title "Response Variability to Sedative Effects of Diazepam in Normal Subjects" @default.
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- W2045642295 doi "https://doi.org/10.1080/16506079309455944" @default.
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