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• W2045644037 abstract "Glucagon-like peptide-1 (GLP-1) receptor imaging is superior to somatostatin receptor subtype 2 (sst₂) imaging in localizing benign insulinomas. Here, the role of GLP-1 and sst₂ receptor imaging in the management of malignant insulinoma patients was investigated. <b>Methods:</b> Eleven patients with malignant insulinoma were prospectively included. ¹¹¹In-[Lys⁴⁰(Ahx-diethylenetriaminepentaacetic acid [DTPA])NH₂]-exendin-4 SPECT/CT, ⁶⁸Ga- DOTATATE PET/CT, and in vitro receptor autoradiography were performed to assess the receptor status and to evaluate the detection rate. <b>Results:</b> GLP-1 receptor targeting was positive in 4 of 11 patients, and sst₂ receptor expression was positive in 8 of 11. In only 1 patient were both receptors expressed. In 1 patient, GLP-1 receptor imaging was the only method that successfully localized the primary tumor in the pancreas. In 3 patients with sst₂-expressing tumors, DOTATATE radiotherapy was effectively applied. <b>Conclusion:</b> As opposed to benign insulinomas, malignant insulinomas often lack GLP-1 receptors. Conversely, malignant insulinomas often express sst₂, which can be targeted therapeutically." @default.
• W2045644037 created "2016-06-24" @default.
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• W2045644037 date "2011-06-16" @default.
• W2045644037 modified "2023-10-02" @default.
• W2045644037 title "Glucagon-Like Peptide-1 Versus Somatostatin Receptor Targeting Reveals 2 Distinct Forms of Malignant Insulinomas" @default.
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• W2045644037 doi "https://doi.org/10.2967/jnumed.110.085142" @default.
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