Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045647564> ?p ?o ?g. }
- W2045647564 endingPage "2879" @default.
- W2045647564 startingPage "2869" @default.
- W2045647564 abstract "ABSTRACT Previously, we found that human papillomavirus type 16 (HPV-16) E5 protein is a tumor rejection antigen and can induce cytotoxic T-lymphocyte (CTL) activity. Therefore, in this study, human leukocyte antigen A*0201 (HLA-A*0201)-restricted human CTL epitopes of HPV-16 E5 protein were identified using a bioinformatics approach, and the abilities of these predicted peptides to induce an immune response in HLA-A*0201 transgenic mice were confirmed by assaying E5-specific CTLs and in vitro-generated CTLs from normal peripheral blood T lymphocytes of HLA-A2-positive human donors. Second, the CTL responses to HLA-A*0201 CTL epitopes (E5 63-71 and E7 11-20) were examined in HPV-16-infected patients with HLA-A2. Third, the effect of HLA-A-type alleles on CTL activities in response to the entire E5 and E7 proteins was examined in cervical cancer patients. E5 and E7 peptides (but not the whole proteins) stimulated E5- and E7-specific CTL recall responses in HPV-16- and HLA-A2-positive cervical cancer patients, and HPV-16 E5 and E7 proteins stimulated naïve T cells in HPV-16-negative cervical cancer patients with HLA-A11 and -A24 haplotypes. In summary, this is the first demonstration that E5 63-71 is an HLA-A*0201-restricted T-cell epitope of HPV-16 E5." @default.
- W2045647564 created "2016-06-24" @default.
- W2045647564 creator A5007128867 @default.
- W2045647564 creator A5029572710 @default.
- W2045647564 creator A5040919506 @default.
- W2045647564 creator A5044114999 @default.
- W2045647564 creator A5070243334 @default.
- W2045647564 creator A5072260694 @default.
- W2045647564 creator A5074072700 @default.
- W2045647564 creator A5083196394 @default.
- W2045647564 date "2007-03-15" @default.
- W2045647564 modified "2023-09-26" @default.
- W2045647564 title "Cytotoxic T-Lymphocyte Responses to Human Papillomavirus Type 16 E5 and E7 Proteins and HLA-A*0201-Restricted T-Cell Peptides in Cervical Cancer Patients" @default.
- W2045647564 cites W1494328783 @default.
- W2045647564 cites W1556098051 @default.
- W2045647564 cites W1656802595 @default.
- W2045647564 cites W1828563947 @default.
- W2045647564 cites W1895370620 @default.
- W2045647564 cites W1940897091 @default.
- W2045647564 cites W1946102895 @default.
- W2045647564 cites W1946675397 @default.
- W2045647564 cites W1950221064 @default.
- W2045647564 cites W1965517166 @default.
- W2045647564 cites W1967757856 @default.
- W2045647564 cites W1981283841 @default.
- W2045647564 cites W1981973325 @default.
- W2045647564 cites W1984861740 @default.
- W2045647564 cites W1988593172 @default.
- W2045647564 cites W1991000785 @default.
- W2045647564 cites W2002198209 @default.
- W2045647564 cites W2018952436 @default.
- W2045647564 cites W2028833566 @default.
- W2045647564 cites W2051571555 @default.
- W2045647564 cites W2055415515 @default.
- W2045647564 cites W2064873017 @default.
- W2045647564 cites W2068807816 @default.
- W2045647564 cites W2069236693 @default.
- W2045647564 cites W2073502069 @default.
- W2045647564 cites W2079893379 @default.
- W2045647564 cites W2082950238 @default.
- W2045647564 cites W2089899954 @default.
- W2045647564 cites W2095903414 @default.
- W2045647564 cites W2098765233 @default.
- W2045647564 cites W2109111910 @default.
- W2045647564 cites W2110456739 @default.
- W2045647564 cites W2116445116 @default.
- W2045647564 cites W2123380997 @default.
- W2045647564 cites W2124035435 @default.
- W2045647564 cites W2124915959 @default.
- W2045647564 cites W2137021531 @default.
- W2045647564 cites W2137465507 @default.
- W2045647564 cites W2138004014 @default.
- W2045647564 cites W2139876308 @default.
- W2045647564 cites W2141143434 @default.
- W2045647564 cites W2142680679 @default.
- W2045647564 cites W2144359412 @default.
- W2045647564 cites W2147173705 @default.
- W2045647564 cites W2148894524 @default.
- W2045647564 cites W2158437850 @default.
- W2045647564 cites W2162044132 @default.
- W2045647564 cites W2165069156 @default.
- W2045647564 cites W2168495423 @default.
- W2045647564 cites W2168766701 @default.
- W2045647564 doi "https://doi.org/10.1128/jvi.02256-06" @default.
- W2045647564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865983" @default.
- W2045647564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17202211" @default.
- W2045647564 hasPublicationYear "2007" @default.
- W2045647564 type Work @default.
- W2045647564 sameAs 2045647564 @default.
- W2045647564 citedByCount "24" @default.
- W2045647564 countsByYear W20456475642012 @default.
- W2045647564 countsByYear W20456475642013 @default.
- W2045647564 countsByYear W20456475642014 @default.
- W2045647564 countsByYear W20456475642015 @default.
- W2045647564 countsByYear W20456475642016 @default.
- W2045647564 countsByYear W20456475642017 @default.
- W2045647564 countsByYear W20456475642018 @default.
- W2045647564 countsByYear W20456475642019 @default.
- W2045647564 countsByYear W20456475642020 @default.
- W2045647564 countsByYear W20456475642021 @default.
- W2045647564 countsByYear W20456475642022 @default.
- W2045647564 crossrefType "journal-article" @default.
- W2045647564 hasAuthorship W2045647564A5007128867 @default.
- W2045647564 hasAuthorship W2045647564A5029572710 @default.
- W2045647564 hasAuthorship W2045647564A5040919506 @default.
- W2045647564 hasAuthorship W2045647564A5044114999 @default.
- W2045647564 hasAuthorship W2045647564A5070243334 @default.
- W2045647564 hasAuthorship W2045647564A5072260694 @default.
- W2045647564 hasAuthorship W2045647564A5074072700 @default.
- W2045647564 hasAuthorship W2045647564A5083196394 @default.
- W2045647564 hasBestOaLocation W20456475642 @default.
- W2045647564 hasConcept C121608353 @default.
- W2045647564 hasConcept C147483822 @default.
- W2045647564 hasConcept C147969180 @default.
- W2045647564 hasConcept C153911025 @default.
- W2045647564 hasConcept C154317977 @default.
- W2045647564 hasConcept C159047783 @default.
- W2045647564 hasConcept C167672396 @default.