Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045647654> ?p ?o ?g. }
- W2045647654 endingPage "13" @default.
- W2045647654 startingPage "8" @default.
- W2045647654 abstract "Elevated plasma levels of lipoprotein (a) [Lp(a)] constitutes an independent risk factor for coronary heart disease, stroke, and restenosis. Over the past years, our understanding of the genetics, metabolism and pathophysiology of Lp(a) have increased considerably. However, the precise mechanism(s) by which this atherogenic lipoprotein mediates the development of atherosclerosis remains unclear. This is partly due to the lack of appropriate animal models since apolipoprotein (a) [apo(a)], a distinct component of Lp(a) is found only in primates and humans. Development of transgenic mice expressing human apo(a) has provided an alternative means to investigate many aspects of Lp(a). However, human apo(a) in transgenic mice can not bind to murine apoB to form Lp(a) particles. In this aspect, we generated transgenic rabbits expressing human apo(a). In the plasma of transgenic rabbits, unlike the plasma of transgenic mice, about 80% of the apo(a) was associated with rabbit apo B and was contained in the fractions with density 1.02-1.10 g/ml, indicating the formation of Lp(a). Our study suggests that transgenic rabbits expressing human apo(a) exhibit efficient assembly of Lp(a) and can be used as an animal model for the study of human Lp(a)." @default.
- W2045647654 created "2016-06-24" @default.
- W2045647654 creator A5045555652 @default.
- W2045647654 creator A5091051331 @default.
- W2045647654 date "2000-01-01" @default.
- W2045647654 modified "2023-10-14" @default.
- W2045647654 title "Transgenic Rabbits Expressing Human Apolipoprotein (a)" @default.
- W2045647654 cites W1531104076 @default.
- W2045647654 cites W1907534963 @default.
- W2045647654 cites W191126138 @default.
- W2045647654 cites W1970055375 @default.
- W2045647654 cites W1972725165 @default.
- W2045647654 cites W1976559252 @default.
- W2045647654 cites W1981135463 @default.
- W2045647654 cites W1983055162 @default.
- W2045647654 cites W1986139246 @default.
- W2045647654 cites W1989069669 @default.
- W2045647654 cites W1994273046 @default.
- W2045647654 cites W1998023491 @default.
- W2045647654 cites W2001691760 @default.
- W2045647654 cites W2006760737 @default.
- W2045647654 cites W2013252870 @default.
- W2045647654 cites W2013525819 @default.
- W2045647654 cites W2022043977 @default.
- W2045647654 cites W2023996177 @default.
- W2045647654 cites W2029003946 @default.
- W2045647654 cites W2034457606 @default.
- W2045647654 cites W2036170644 @default.
- W2045647654 cites W2052249127 @default.
- W2045647654 cites W2072437587 @default.
- W2045647654 cites W2073907386 @default.
- W2045647654 cites W2092506349 @default.
- W2045647654 cites W2096366405 @default.
- W2045647654 cites W2097580954 @default.
- W2045647654 cites W2105319061 @default.
- W2045647654 cites W2110075602 @default.
- W2045647654 cites W2113106232 @default.
- W2045647654 cites W2117630610 @default.
- W2045647654 cites W2118721393 @default.
- W2045647654 cites W2156315439 @default.
- W2045647654 cites W2166083242 @default.
- W2045647654 cites W2185505382 @default.
- W2045647654 cites W2443135943 @default.
- W2045647654 doi "https://doi.org/10.5551/jat1994.7.8" @default.
- W2045647654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11425047" @default.
- W2045647654 hasPublicationYear "2000" @default.
- W2045647654 type Work @default.
- W2045647654 sameAs 2045647654 @default.
- W2045647654 citedByCount "9" @default.
- W2045647654 countsByYear W20456476542012 @default.
- W2045647654 countsByYear W20456476542016 @default.
- W2045647654 countsByYear W20456476542022 @default.
- W2045647654 crossrefType "journal-article" @default.
- W2045647654 hasAuthorship W2045647654A5045555652 @default.
- W2045647654 hasAuthorship W2045647654A5091051331 @default.
- W2045647654 hasConcept C10162356 @default.
- W2045647654 hasConcept C102230213 @default.
- W2045647654 hasConcept C104317684 @default.
- W2045647654 hasConcept C126322002 @default.
- W2045647654 hasConcept C134018914 @default.
- W2045647654 hasConcept C141035611 @default.
- W2045647654 hasConcept C172268261 @default.
- W2045647654 hasConcept C185592680 @default.
- W2045647654 hasConcept C2776104379 @default.
- W2045647654 hasConcept C2778117688 @default.
- W2045647654 hasConcept C2778163477 @default.
- W2045647654 hasConcept C2780072125 @default.
- W2045647654 hasConcept C3020134792 @default.
- W2045647654 hasConcept C43617362 @default.
- W2045647654 hasConcept C54355233 @default.
- W2045647654 hasConcept C62746215 @default.
- W2045647654 hasConcept C71924100 @default.
- W2045647654 hasConcept C86803240 @default.
- W2045647654 hasConceptScore W2045647654C10162356 @default.
- W2045647654 hasConceptScore W2045647654C102230213 @default.
- W2045647654 hasConceptScore W2045647654C104317684 @default.
- W2045647654 hasConceptScore W2045647654C126322002 @default.
- W2045647654 hasConceptScore W2045647654C134018914 @default.
- W2045647654 hasConceptScore W2045647654C141035611 @default.
- W2045647654 hasConceptScore W2045647654C172268261 @default.
- W2045647654 hasConceptScore W2045647654C185592680 @default.
- W2045647654 hasConceptScore W2045647654C2776104379 @default.
- W2045647654 hasConceptScore W2045647654C2778117688 @default.
- W2045647654 hasConceptScore W2045647654C2778163477 @default.
- W2045647654 hasConceptScore W2045647654C2780072125 @default.
- W2045647654 hasConceptScore W2045647654C3020134792 @default.
- W2045647654 hasConceptScore W2045647654C43617362 @default.
- W2045647654 hasConceptScore W2045647654C54355233 @default.
- W2045647654 hasConceptScore W2045647654C62746215 @default.
- W2045647654 hasConceptScore W2045647654C71924100 @default.
- W2045647654 hasConceptScore W2045647654C86803240 @default.
- W2045647654 hasIssue "1" @default.
- W2045647654 hasLocation W20456476541 @default.
- W2045647654 hasLocation W20456476542 @default.
- W2045647654 hasOpenAccess W2045647654 @default.
- W2045647654 hasPrimaryLocation W20456476541 @default.
- W2045647654 hasRelatedWork W1974976899 @default.
- W2045647654 hasRelatedWork W2022043977 @default.