FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045650908> ?p ?o ?g. }

• W2045650908 endingPage "419" @default.
• W2045650908 startingPage "414" @default.
• W2045650908 abstract "Understanding developmental changes in contractility is critical to improving therapies for young cardiac patients. Isometric developed force was measured in human ventricular muscle strips from two age groups: newborns (<2 wk) and infants (3–14 mo) undergoing repair for congenital heart defects. Muscle strips were paced at several cycle lengths (CLs) to determine the force frequency response (FFR). Changes in Na/Ca exchanger (NCX), sarcoplasmic reticulum Ca-ATPase (SERCA), and phospholamban (PLB) were characterized. At CL 2000 ms, developed force was similar in the two groups. Decreasing CL increased developed force in the infant group to 131 ± 8% (CL 1000 ms) and 157 ± 18% (CL 500 ms) demonstrating a positive FFR. The FFR in the newborn group was flat. NCX mRNA and protein levels were significantly larger in the newborn than infant group whereas SERCA levels were unchanged. PLB mRNA levels and PLB/SERCA ratio increased with age. Immunostaining for NCX in isolated newborn cells showed peripheral staining. In infant cells, NCX was also found in T-tubules. SERCA staining was regular and striated in both groups. This study shows for the first time that the newborn human ventricle has a flat FFR, which increases with age and may be caused by developmental changes in calcium handling." @default.
• W2045650908 created "2016-06-24" @default.
• W2045650908 creator A5009162503 @default.
• W2045650908 creator A5015245515 @default.
• W2045650908 creator A5026673697 @default.
• W2045650908 creator A5042482544 @default.
• W2045650908 creator A5046351077 @default.
• W2045650908 creator A5058057464 @default.
• W2045650908 creator A5071296783 @default.
• W2045650908 creator A5072658861 @default.
• W2045650908 creator A5082163778 @default.
• W2045650908 creator A5083072147 @default.
• W2045650908 creator A5087767646 @default.
• W2045650908 date "2009-04-01" @default.
• W2045650908 modified "2023-10-01" @default.
• W2045650908 title "Force Frequency Relationship of the Human Ventricle Increases During Early Postnatal Development" @default.
• W2045650908 cites W1552975364 @default.
• W2045650908 cites W1967428301 @default.
• W2045650908 cites W1972370207 @default.
• W2045650908 cites W1987126455 @default.
• W2045650908 cites W1996780591 @default.
• W2045650908 cites W1999239950 @default.
• W2045650908 cites W2002429526 @default.
• W2045650908 cites W2006997901 @default.
• W2045650908 cites W2012013924 @default.
• W2045650908 cites W2013195452 @default.
• W2045650908 cites W2023470676 @default.
• W2045650908 cites W2030698636 @default.
• W2045650908 cites W2037058971 @default.
• W2045650908 cites W2038499889 @default.
• W2045650908 cites W2047394035 @default.
• W2045650908 cites W2051436762 @default.
• W2045650908 cites W2059972452 @default.
• W2045650908 cites W2066118117 @default.
• W2045650908 cites W2071639534 @default.
• W2045650908 cites W2075745285 @default.
• W2045650908 cites W2078991145 @default.
• W2045650908 cites W2081725793 @default.
• W2045650908 cites W2093520406 @default.
• W2045650908 cites W2103105155 @default.
• W2045650908 cites W2118810404 @default.
• W2045650908 cites W2127162267 @default.
• W2045650908 cites W2131224601 @default.
• W2045650908 cites W2136212502 @default.
• W2045650908 cites W2157615041 @default.
• W2045650908 cites W2158179261 @default.
• W2045650908 cites W2171260775 @default.
• W2045650908 cites W2172519975 @default.
• W2045650908 cites W4293247451 @default.
• W2045650908 doi "https://doi.org/10.1203/pdr.0b013e318199093c" @default.
• W2045650908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2788428" @default.
• W2045650908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19127223" @default.
• W2045650908 hasPublicationYear "2009" @default.
• W2045650908 type Work @default.
• W2045650908 sameAs 2045650908 @default.
• W2045650908 citedByCount "73" @default.
• W2045650908 countsByYear W20456509082012 @default.
• W2045650908 countsByYear W20456509082013 @default.
• W2045650908 countsByYear W20456509082014 @default.
• W2045650908 countsByYear W20456509082015 @default.
• W2045650908 countsByYear W20456509082016 @default.
• W2045650908 countsByYear W20456509082017 @default.
• W2045650908 countsByYear W20456509082018 @default.
• W2045650908 countsByYear W20456509082019 @default.
• W2045650908 countsByYear W20456509082020 @default.
• W2045650908 countsByYear W20456509082021 @default.
• W2045650908 countsByYear W20456509082022 @default.
• W2045650908 countsByYear W20456509082023 @default.
• W2045650908 crossrefType "journal-article" @default.
• W2045650908 hasAuthorship W2045650908A5009162503 @default.
• W2045650908 hasAuthorship W2045650908A5015245515 @default.
• W2045650908 hasAuthorship W2045650908A5026673697 @default.
• W2045650908 hasAuthorship W2045650908A5042482544 @default.
• W2045650908 hasAuthorship W2045650908A5046351077 @default.
• W2045650908 hasAuthorship W2045650908A5058057464 @default.
• W2045650908 hasAuthorship W2045650908A5071296783 @default.
• W2045650908 hasAuthorship W2045650908A5072658861 @default.
• W2045650908 hasAuthorship W2045650908A5082163778 @default.
• W2045650908 hasAuthorship W2045650908A5083072147 @default.
• W2045650908 hasAuthorship W2045650908A5087767646 @default.
• W2045650908 hasBestOaLocation W20456509081 @default.
• W2045650908 hasConcept C103486182 @default.
• W2045650908 hasConcept C126322002 @default.
• W2045650908 hasConcept C134018914 @default.
• W2045650908 hasConcept C158617107 @default.
• W2045650908 hasConcept C164705383 @default.
• W2045650908 hasConcept C17137333 @default.
• W2045650908 hasConcept C181199279 @default.
• W2045650908 hasConcept C185592680 @default.
• W2045650908 hasConcept C23265538 @default.
• W2045650908 hasConcept C2778921608 @default.
• W2045650908 hasConcept C2781414619 @default.
• W2045650908 hasConcept C39133596 @default.
• W2045650908 hasConcept C519063684 @default.
• W2045650908 hasConcept C55493867 @default.
• W2045650908 hasConcept C57900726 @default.
• W2045650908 hasConcept C71924100 @default.
• W2045650908 hasConcept C84393581 @default.

• next