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• W2045651205 endingPage "4358" @default.
• W2045651205 startingPage "4358" @default.
• W2045651205 abstract "Two drug-drug co-crystals of the anti-tuberculosis drugs isoniazid (INH), pyrazinamide (PYR) and 4-aminosalicylic acid (PAS) are reported. The first is the 1 : 1 molecular complex of INH and PAS. The second is the monohydrate of the 1 : 1 complex of PYR and PAS. The crystal structures of both co-crystals are characterized by a number of hydrogen bonded synthons. Hydrogen bonding of the COOH⋯Npyridine type is found in both cases. In the INH : PAS co-crystal, there are two symmetry independent COOH⋯Npyridine hydrogen bonds. In one of these, the H-atom is located on the carboxylic group and is indicative of a co-crystal. In the second case, partial proton transfer occurs across the hydrogen bond, and the extent of proton transfer depends on the temperature. This is more indicative of a salt. Drug-drug co-crystals may have some bearing in the treatment of tuberculosis." @default.
• W2045651205 created "2016-06-24" @default.
• W2045651205 creator A5054702435 @default.
• W2045651205 creator A5060583781 @default.
• W2045651205 creator A5064424943 @default.
• W2045651205 date "2011-01-01" @default.
• W2045651205 modified "2023-10-13" @default.
• W2045651205 title "Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid" @default.
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• W2045651205 doi "https://doi.org/10.1039/c0ce00842g" @default.
• W2045651205 hasPublicationYear "2011" @default.
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