FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045656102> ?p ?o ?g. }

• W2045656102 endingPage "315" @default.
• W2045656102 startingPage "304" @default.
• W2045656102 abstract "Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some types of learning and memory. Interestingly, a major site of adult neurogenesis, the hippocampus, is important in the formation of drug-context associations and in the mediation of drug-taking and drug-seeking behaviors in animal models of addiction. Correlative evidence suggests an inverse relationship between hippocampal neurogenesis and drug-taking or drug-seeking behaviors, but the lack of a causative link has made the relationship between adult-generated neurons and addiction unclear. We used rat intravenous cocaine self-administration in rodents, a clinically relevant animal model of addiction, to test the hypothesis that suppression of adult hippocampal neurogenesis enhances vulnerability to addiction and relapse. Suppression of adult hippocampal neurogenesis via cranial irradiation before drug-taking significantly increased cocaine self-administration on both fixed-ratio and progressive-ratio schedules, as well as induced a vertical shift in the dose-response curve. This was not a general enhancement of learning, motivation, or locomotion, because sucrose self-administration and locomotor activity were unchanged in irradiated rats. Suppression of adult hippocampal neurogenesis after drug-taking significantly enhanced resistance to extinction of drug-seeking behavior. These studies identify reduced adult hippocampal neurogenesis as a novel risk factor for addiction-related behaviors in an animal model of cocaine addiction. Furthermore, they suggest that therapeutics to specifically increase or stabilize adult hippocampal neurogenesis could aid in preventing initial addiction as well as future relapse." @default.
• W2045656102 created "2016-06-24" @default.
• W2045656102 creator A5016113584 @default.
• W2045656102 creator A5029014154 @default.
• W2045656102 creator A5060118711 @default.
• W2045656102 creator A5090611296 @default.
• W2045656102 date "2010-01-06" @default.
• W2045656102 modified "2023-10-12" @default.
• W2045656102 title "Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction" @default.
• W2045656102 cites W1504817278 @default.
• W2045656102 cites W1590632482 @default.
• W2045656102 cites W164290047 @default.
• W2045656102 cites W1823225248 @default.
• W2045656102 cites W1949947575 @default.
• W2045656102 cites W1967713900 @default.
• W2045656102 cites W1971303103 @default.
• W2045656102 cites W1974791004 @default.
• W2045656102 cites W1976068599 @default.
• W2045656102 cites W1977756547 @default.
• W2045656102 cites W1979338446 @default.
• W2045656102 cites W1981032252 @default.
• W2045656102 cites W1983038420 @default.
• W2045656102 cites W1988182239 @default.
• W2045656102 cites W1990650114 @default.
• W2045656102 cites W1991154371 @default.
• W2045656102 cites W1994886004 @default.
• W2045656102 cites W1995188451 @default.
• W2045656102 cites W1996269662 @default.
• W2045656102 cites W2001515438 @default.
• W2045656102 cites W2004137484 @default.
• W2045656102 cites W2006780539 @default.
• W2045656102 cites W2009429333 @default.
• W2045656102 cites W2010053974 @default.
• W2045656102 cites W2015775161 @default.
• W2045656102 cites W2017341887 @default.
• W2045656102 cites W2018040130 @default.
• W2045656102 cites W2018743597 @default.
• W2045656102 cites W2019888004 @default.
• W2045656102 cites W2022372660 @default.
• W2045656102 cites W2023136242 @default.
• W2045656102 cites W2037877714 @default.
• W2045656102 cites W2038459152 @default.
• W2045656102 cites W2044321235 @default.
• W2045656102 cites W2045571228 @default.
• W2045656102 cites W2049981427 @default.
• W2045656102 cites W2050938473 @default.
• W2045656102 cites W2054053664 @default.
• W2045656102 cites W2057135100 @default.
• W2045656102 cites W2060161739 @default.
• W2045656102 cites W2064461643 @default.
• W2045656102 cites W2065846787 @default.
• W2045656102 cites W2070794162 @default.
• W2045656102 cites W2074615095 @default.
• W2045656102 cites W2075072537 @default.
• W2045656102 cites W2075257572 @default.
• W2045656102 cites W2077392553 @default.
• W2045656102 cites W2081194850 @default.
• W2045656102 cites W2081431034 @default.
• W2045656102 cites W2084376094 @default.
• W2045656102 cites W2085155996 @default.
• W2045656102 cites W2087354578 @default.
• W2045656102 cites W2087957865 @default.
• W2045656102 cites W2091482984 @default.
• W2045656102 cites W2092139956 @default.
• W2045656102 cites W2092499931 @default.
• W2045656102 cites W2097351636 @default.
• W2045656102 cites W2099344713 @default.
• W2045656102 cites W2103791867 @default.
• W2045656102 cites W2105086774 @default.
• W2045656102 cites W2105590889 @default.
• W2045656102 cites W2108461283 @default.
• W2045656102 cites W2113631648 @default.
• W2045656102 cites W2119222668 @default.
• W2045656102 cites W2124427850 @default.
• W2045656102 cites W2133565799 @default.
• W2045656102 cites W2136108338 @default.
• W2045656102 cites W2136801447 @default.
• W2045656102 cites W2140837625 @default.
• W2045656102 cites W2145884075 @default.
• W2045656102 cites W2148239264 @default.
• W2045656102 cites W2150299732 @default.
• W2045656102 cites W2157615237 @default.
• W2045656102 cites W2166417233 @default.
• W2045656102 cites W2167626393 @default.
• W2045656102 cites W2169145097 @default.
• W2045656102 cites W4248161408 @default.
• W2045656102 doi "https://doi.org/10.1523/jneurosci.4256-09.2010" @default.
• W2045656102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844797" @default.
• W2045656102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20053911" @default.
• W2045656102 hasPublicationYear "2010" @default.
• W2045656102 type Work @default.
• W2045656102 sameAs 2045656102 @default.
• W2045656102 citedByCount "189" @default.
• W2045656102 countsByYear W20456561022012 @default.
• W2045656102 countsByYear W20456561022013 @default.
• W2045656102 countsByYear W20456561022014 @default.
• W2045656102 countsByYear W20456561022015 @default.
• W2045656102 countsByYear W20456561022016 @default.

• next