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• W2045660156 startingPage "e6919" @default.
• W2045660156 abstract "In Alternative Lengthening of Telomeres (ALT) cell lines, specific nuclear bodies called APBs (ALT-associated PML bodies) concentrate telomeric DNA, shelterin components and recombination factors associated with telomere recombination. Topoisomerase IIIalpha (Topo III) is an essential telomeric-associated factor in ALT cells. We show here that the binding of Topo III to telomeric G-overhang is modulated by G-quadruplex formation. Topo III binding to G-quadruplex-forming oligonucleotides was strongly inhibited by telomestatin, a potent and specific G-quadruplex ligand. In ALT cells, telomestatin treatment resulted in the depletion of the Topo III/BLM/TRF2 complex and the disruption of APBs and led to the segregation of PML, shelterin components and Topo III. Interestingly, a DNA damage response was observed at telomeres in telomestatin-treated cells. These data indicate the importance of G-quadruplex stabilization during telomere maintenance in ALT cells. The function of TRF2/Topo III/BLM in the resolution of replication intermediates at telomeres is discussed." @default.
• W2045660156 created "2016-06-24" @default.
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• W2045660156 date "2009-09-09" @default.
• W2045660156 modified "2023-10-18" @default.
• W2045660156 title "The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells" @default.
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• W2045660156 doi "https://doi.org/10.1371/journal.pone.0006919" @default.
• W2045660156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2732903" @default.
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