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- W2045663003 abstract "In Alzheimer's disease, abnormal processing of the amyloid precursor protein (APP) is thought to play an important role in amyloid deposition. We investigated the effect of heparin, a highly sulfated glycosaminoglycan related to heparan sulfate, on the secretion of the ß-secretase cleavage product of APP (sAPPß) in a human neuroblastoma cell line. Heparin induced an increase in the secretion of total APP, and an even greater relative increase in the secretion of sAPPß. The effect on sAPPß was specific to heparin. These data support the hypothesis that highly sulfated heparan sulfate proteoglycans may promote amyloidogenic pathways of APP metabolism." @default.
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- W2045663003 date "1997-06-07" @default.
- W2045663003 modified "2023-10-17" @default.
- W2045663003 title "Heparin promotes ß-secretase cleavage of the Alzheimer's amyloid precursor protein" @default.
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- W2045663003 doi "https://doi.org/10.1016/s0197-0186(96)00103-9" @default.
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