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- W2045664562 abstract "Peripheral blood lymphocytes were observed to have a defect in adenosine 3',5'-monophosphate (cAMP) metabolism during acute malaria infection which reversed once parasites were eliminated from the host circulation. The defect was characterized by decreased intracellular cAMP levels in lymphocytes and by hyporesponsiveness to adenosine or forskolin stimulation of cAMP production. These biochemical changes appeared to correlate functionally with a reduction in the proliferative response of lymphocytes to concanavalin A. A defect in the second messenger role of cAMP in immune effector cells may underlie immunosuppression in malaria infection." @default.
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- W2045664562 date "1990-05-01" @default.
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- W2045664562 title "Reversible defect in cAMP metabolism in lymphocytes in malaria infection" @default.
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- W2045664562 doi "https://doi.org/10.1016/0162-3109(90)90066-n" @default.
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