Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045665636> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2045665636 endingPage "1156" @default.
- W2045665636 startingPage "1152" @default.
- W2045665636 abstract "The management of severe pain may require balanced analgesia, involving the use of analgesics with different modes of action. Clonidine, an alpha(2)-adrenoreceptor agonist produces analgesia by itself as well as when given with morphine and local anesthetics. Ketorolac is indicated for the management of moderately severe acute pain and causes analgesia equivalent to morphine. This study was designed to investigate whether the addition of ketorolac promotes antinociception produced by intrathecal administration of clonidine in male Sprague-Dawley rats. Intrathecal injection of clonidine (1-30 microg) induced a dose-dependent increase in antinociception as measured by the tail flick (TF) and hot plate tests. Ketorolac alone (150-600 microg) increased the antinociception by 50%-60% only in the TF test. Ketorolac (10 microg) decreased clonidine (10 microg)-induced antinociception from 69.1% +/- 7.8% to 23.5% +/- 1. 6% (P < 0.05) in the TF test and 35.7% +/- 4.7% to 4.5% +/- 0.1% (P < 0.05) maximum possible effect in the hot plate test. Ketorolac also antagonized the effect of 30 microg of clonidine. The opioid receptor antagonist naloxone antagonized the antinociceptive effect of clonidine and ketorolac, indicating the involvement of the opioid system in the antinociception produced by clonidine or ketorolac. However, neither clonidine nor ketorolac (10(-8) to 10(-3) M) inhibited the binding of specific ligands to mu-, delta-, and kappa-opioid receptors, indicating a lack of direct interaction of clonidine and ketorolac with opioid receptors. These results suggest that intrathecal injection of ketorolac antagonizes the antinociception produced by clonidine." @default.
- W2045665636 created "2016-06-24" @default.
- W2045665636 creator A5007678356 @default.
- W2045665636 creator A5072259478 @default.
- W2045665636 date "2000-05-01" @default.
- W2045665636 modified "2023-10-14" @default.
- W2045665636 title "Antagonism of Antinociception Produced by Intrathecal Clonidine by Ketorolac in the Rat: The Role of the Opioid System" @default.
- W2045665636 cites W1964096857 @default.
- W2045665636 cites W1966718220 @default.
- W2045665636 cites W2015578225 @default.
- W2045665636 cites W2015898953 @default.
- W2045665636 cites W2039340001 @default.
- W2045665636 cites W2051675043 @default.
- W2045665636 cites W2064873592 @default.
- W2045665636 cites W2121433470 @default.
- W2045665636 cites W2134852027 @default.
- W2045665636 cites W2148853922 @default.
- W2045665636 cites W4243974836 @default.
- W2045665636 cites W4327634976 @default.
- W2045665636 doi "https://doi.org/10.1097/00000539-200005000-00028" @default.
- W2045665636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10781470" @default.
- W2045665636 hasPublicationYear "2000" @default.
- W2045665636 type Work @default.
- W2045665636 sameAs 2045665636 @default.
- W2045665636 citedByCount "17" @default.
- W2045665636 countsByYear W20456656362012 @default.
- W2045665636 crossrefType "journal-article" @default.
- W2045665636 hasAuthorship W2045665636A5007678356 @default.
- W2045665636 hasAuthorship W2045665636A5072259478 @default.
- W2045665636 hasBestOaLocation W20456656361 @default.
- W2045665636 hasConcept C126322002 @default.
- W2045665636 hasConcept C15490471 @default.
- W2045665636 hasConcept C170493617 @default.
- W2045665636 hasConcept C2776885963 @default.
- W2045665636 hasConcept C2777389121 @default.
- W2045665636 hasConcept C2778399450 @default.
- W2045665636 hasConcept C2778446825 @default.
- W2045665636 hasConcept C2778750930 @default.
- W2045665636 hasConcept C2778938600 @default.
- W2045665636 hasConcept C2779886867 @default.
- W2045665636 hasConcept C2780820201 @default.
- W2045665636 hasConcept C2781063702 @default.
- W2045665636 hasConcept C42219234 @default.
- W2045665636 hasConcept C71924100 @default.
- W2045665636 hasConcept C98274493 @default.
- W2045665636 hasConceptScore W2045665636C126322002 @default.
- W2045665636 hasConceptScore W2045665636C15490471 @default.
- W2045665636 hasConceptScore W2045665636C170493617 @default.
- W2045665636 hasConceptScore W2045665636C2776885963 @default.
- W2045665636 hasConceptScore W2045665636C2777389121 @default.
- W2045665636 hasConceptScore W2045665636C2778399450 @default.
- W2045665636 hasConceptScore W2045665636C2778446825 @default.
- W2045665636 hasConceptScore W2045665636C2778750930 @default.
- W2045665636 hasConceptScore W2045665636C2778938600 @default.
- W2045665636 hasConceptScore W2045665636C2779886867 @default.
- W2045665636 hasConceptScore W2045665636C2780820201 @default.
- W2045665636 hasConceptScore W2045665636C2781063702 @default.
- W2045665636 hasConceptScore W2045665636C42219234 @default.
- W2045665636 hasConceptScore W2045665636C71924100 @default.
- W2045665636 hasConceptScore W2045665636C98274493 @default.
- W2045665636 hasIssue "5" @default.
- W2045665636 hasLocation W20456656361 @default.
- W2045665636 hasLocation W20456656362 @default.
- W2045665636 hasOpenAccess W2045665636 @default.
- W2045665636 hasPrimaryLocation W20456656361 @default.
- W2045665636 hasRelatedWork W2006431109 @default.
- W2045665636 hasRelatedWork W2017543502 @default.
- W2045665636 hasRelatedWork W2039340001 @default.
- W2045665636 hasRelatedWork W2045665636 @default.
- W2045665636 hasRelatedWork W2067032885 @default.
- W2045665636 hasRelatedWork W2070795956 @default.
- W2045665636 hasRelatedWork W2072203697 @default.
- W2045665636 hasRelatedWork W2414256136 @default.
- W2045665636 hasRelatedWork W2565543174 @default.
- W2045665636 hasRelatedWork W4318830844 @default.
- W2045665636 hasVolume "90" @default.
- W2045665636 isParatext "false" @default.
- W2045665636 isRetracted "false" @default.
- W2045665636 magId "2045665636" @default.
- W2045665636 workType "article" @default.