Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045666128> ?p ?o ?g. }
- W2045666128 endingPage "121" @default.
- W2045666128 startingPage "113" @default.
- W2045666128 abstract "<h3>Background:</h3> Long-term administration of the dopamine (DA) D2-like (D3/2) receptor agonist pramipexole (PPX) has been previously found to desensitize D2 autoreceptors, thereby allowing a normalization of the firing of DA neurons and serotonin (5-HT)<sub>1A</sub> autoreceptors, permitting an enhancement of the spontaneous firing of 5-HT neurons. We hypothesized that PPX would increase overall DA and 5-HT neurotransmission in the forebrain as a result of these changes at the presynaptic level. <h3>Methods:</h3> Osmotic minipumps were implanted subcutaneously in male Sprague-Dawley rats, delivering PPX at a dose of 1 mg/kg/d for 14 days. The in vivo electrophysiologic microiontophoretic experiments were carried out in anesthetized rats. <h3>Results:</h3> The sensitivity of postsynaptic D2 receptors in the prefrontal cortex (PFC) remained unaltered following PPX administration, as indicated by the unchanged responsiveness to the microiontophoretic application of DA. Their tonic activation was, however, significantly increased by 104% compared with the control level. The sensitivity of postsynaptic 5-HT<sub>1A</sub> receptors was not altered, as indicated by the unchanged responsiveness to the microiontophoretic application of 5-HT. Similar to other antidepressant treatments, long-term PPX administration enhanced the tonic activation of 5-HT<sub>1A</sub> receptors on CA3 pyramidal neurons by 142% compared with the control level. <h3>Limitations:</h3> The assessment of DA and 5-HT neuronal tone was restricted to the PFC and the hippocampus, respectively. <h3>Conclusion:</h3> Chronic PPX administration led to a net enhancement in DA and 5-HT neurotransmission, as indicated by the increased tonic activation of postsynaptic D2 and 5-HT<sub>1A</sub> receptors in forebrain structures." @default.
- W2045666128 created "2016-06-24" @default.
- W2045666128 creator A5002538047 @default.
- W2045666128 creator A5014960520 @default.
- W2045666128 creator A5016283932 @default.
- W2045666128 date "2012-03-01" @default.
- W2045666128 modified "2023-10-05" @default.
- W2045666128 title "Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain" @default.
- W2045666128 cites W1018360976 @default.
- W2045666128 cites W126446314 @default.
- W2045666128 cites W1503601165 @default.
- W2045666128 cites W1509868652 @default.
- W2045666128 cites W1589992431 @default.
- W2045666128 cites W1662108418 @default.
- W2045666128 cites W1874130433 @default.
- W2045666128 cites W1928975456 @default.
- W2045666128 cites W1969717350 @default.
- W2045666128 cites W1973371295 @default.
- W2045666128 cites W1973587070 @default.
- W2045666128 cites W1979867194 @default.
- W2045666128 cites W1980281322 @default.
- W2045666128 cites W1984113489 @default.
- W2045666128 cites W1984434848 @default.
- W2045666128 cites W1986779034 @default.
- W2045666128 cites W1987556089 @default.
- W2045666128 cites W1988766176 @default.
- W2045666128 cites W1990128139 @default.
- W2045666128 cites W1995534937 @default.
- W2045666128 cites W1996310579 @default.
- W2045666128 cites W1997245512 @default.
- W2045666128 cites W1997635941 @default.
- W2045666128 cites W2002276438 @default.
- W2045666128 cites W2002834809 @default.
- W2045666128 cites W2007746109 @default.
- W2045666128 cites W2010865597 @default.
- W2045666128 cites W2026301477 @default.
- W2045666128 cites W2027495209 @default.
- W2045666128 cites W2027721376 @default.
- W2045666128 cites W2028980996 @default.
- W2045666128 cites W2033043582 @default.
- W2045666128 cites W2033619007 @default.
- W2045666128 cites W2037788330 @default.
- W2045666128 cites W2038664574 @default.
- W2045666128 cites W2039646168 @default.
- W2045666128 cites W2040089027 @default.
- W2045666128 cites W2041487100 @default.
- W2045666128 cites W2050386004 @default.
- W2045666128 cites W2051498210 @default.
- W2045666128 cites W2053042086 @default.
- W2045666128 cites W2053556318 @default.
- W2045666128 cites W2062254322 @default.
- W2045666128 cites W2068508452 @default.
- W2045666128 cites W2068816850 @default.
- W2045666128 cites W2072470884 @default.
- W2045666128 cites W2076201141 @default.
- W2045666128 cites W2086880198 @default.
- W2045666128 cites W2087526026 @default.
- W2045666128 cites W2088495467 @default.
- W2045666128 cites W2090063914 @default.
- W2045666128 cites W2109620132 @default.
- W2045666128 cites W2111835286 @default.
- W2045666128 cites W2120471995 @default.
- W2045666128 cites W2132969335 @default.
- W2045666128 cites W2133371501 @default.
- W2045666128 cites W2138538218 @default.
- W2045666128 cites W2142786767 @default.
- W2045666128 cites W2144538553 @default.
- W2045666128 cites W2146747402 @default.
- W2045666128 cites W2147099798 @default.
- W2045666128 cites W2147969224 @default.
- W2045666128 cites W2148239264 @default.
- W2045666128 cites W2149639629 @default.
- W2045666128 cites W2163815564 @default.
- W2045666128 cites W2170513659 @default.
- W2045666128 cites W2249669156 @default.
- W2045666128 cites W2302128506 @default.
- W2045666128 cites W23374646 @default.
- W2045666128 cites W3134891749 @default.
- W2045666128 cites W989040792 @default.
- W2045666128 doi "https://doi.org/10.1503/jpn.110038" @default.
- W2045666128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3297071" @default.
- W2045666128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22023785" @default.
- W2045666128 hasPublicationYear "2012" @default.
- W2045666128 type Work @default.
- W2045666128 sameAs 2045666128 @default.
- W2045666128 citedByCount "33" @default.
- W2045666128 countsByYear W20456661282012 @default.
- W2045666128 countsByYear W20456661282013 @default.
- W2045666128 countsByYear W20456661282014 @default.
- W2045666128 countsByYear W20456661282015 @default.
- W2045666128 countsByYear W20456661282016 @default.
- W2045666128 countsByYear W20456661282017 @default.
- W2045666128 countsByYear W20456661282018 @default.
- W2045666128 countsByYear W20456661282019 @default.
- W2045666128 countsByYear W20456661282020 @default.
- W2045666128 countsByYear W20456661282021 @default.
- W2045666128 countsByYear W20456661282022 @default.
- W2045666128 countsByYear W20456661282023 @default.