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- W2045666790 abstract "The omega-3 (n-3) long-chain polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are crucial to normal brain functioning. Evidence in human studies suggests a link between n-3 PUFA and cognition in ageing; lower plasma and erythrocyte levels of n-3 have been associated with the presence of dementia, greater risk of developing dementia, cognitive decline, and lower cognitive function in older age. However, results from such observational studies are currently inconclusive. The objective is to examine relationships between erythrocyte membrane levels of n-3 PUFAs and cognitive functioning, comprehensively assessed, in a sample of cognitively-healthy (MMSE > 23) older participants, and determine whether relationships differ depending on APOE ϵ4 allele status. Results are from the baseline data of the EPOCH (older people, omega-3, and cognitive health) trial: An 18-month parallel, randomised, double-blind, placebo-controlled trial with repeated measures every 6 months, examining the effect of fish-oil (DHA-rich) on age-related cognitive decline. Participants were 391 (46.3% male) community-dwelling adults, aged 65-90 years (M = 73.1, SD = 5.5), with a mean of 12.9 years of education (SD = 3.8). An extensive battery of cognitive tasks were administered to assess the following cognitive constructs; working memory, reasoning, short-term memory, long-term memory and retrieval, inhibition, processing speed and perceptual speed. Erythrocyte levels of n-3 fatty acids were measured and APOE genotype was assessed. Factor scores from confirmatory factor analytic models of the cognitive domains constitute the dependant variables used in analyses. Multiple regression was used to examine relationships between erythrocyte membrane levels of n-3 PUFA and the cognitive constructs, controlling for possible confounding factors including physical activity, smoking status, age, and years of education. Analyses were conducted for the whole sample as well as sub-samples defined by carriage of the APOE ϵ4 allele. Associations between erythrocyte levels of n-3 PUFA, cognitive functioning, and carriage of the APOE ϵ4 allele will be discussed." @default.
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- W2045666790 date "2009-07-01" @default.
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- W2045666790 title "P4-309: Omega-3 Polyunsaturated Fatty Acids, Apoe ϵ 4 Allele Status, And Cognitive Functioning In Community-dwelling Older Adults" @default.
- W2045666790 doi "https://doi.org/10.1016/j.jalz.2009.07.088" @default.
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