FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045667028> ?p ?o ?g. }

• W2045667028 endingPage "6053" @default.
• W2045667028 startingPage "6040" @default.
• W2045667028 abstract "We generated atomic coordinates of an artificial protein that was recently synthesized to model the central part of the native cytochrome b (Cb) subunit consisting of a four-helix bundle with two hemes. Since no X-ray structure is available, the structural elements of the artificial Cb were assembled from scratch using all known chemical and structural information available and avoiding strain as much as possible. Molecular dynamics (MD) simulations applied to this model protein exhibited root-mean-square deviations as small as those obtained from MD simulations starting with the crystal structure of the native Cb subunit. This demonstrates that the modeled structure of the artificial Cb is relatively rigid and strain-free. The model structure of the artificial Cb was used to determine the redox potentials of the two hemes by calculating the electrostatic energies from the solution of the linearized Poisson−Boltzmann equation (LPBE). The calculated redox potentials agree within 20 meV with the experimentally measured values. The dependence of the redox potentials of the hemes on the protein environment was analyzed. Accordingly, the total shift in the redox potentials is mainly due to the low dielectric medium of the protein, the protein backbone charges, and the salt bridges formed between the arginines and the propionic acid groups of the hemes. The difference in the shift of the redox potentials is due to the interactions with the hydrophilic side chains and the salt bridges formed with the propionic acids of the hemes. For comparison and to test the computational procedure, the redox potentials of the two hemes in the native Cb from the cytochrome bc1 (Cbc1) complex were also calculated. Also in this case the computed redox potentials agree well with experiments." @default.
• W2045667028 created "2016-06-24" @default.
• W2045667028 creator A5005741691 @default.
• W2045667028 creator A5020076636 @default.
• W2045667028 creator A5024132636 @default.
• W2045667028 creator A5043534314 @default.
• W2045667028 date "2001-06-01" @default.
• W2045667028 modified "2023-10-03" @default.
• W2045667028 title "Artificial Cytochrome <i>b</i>: Computer Modeling and Evaluation of Redox Potentials" @default.
• W2045667028 cites W1630368370 @default.
• W2045667028 cites W1966857278 @default.
• W2045667028 cites W1972854336 @default.
• W2045667028 cites W1975249312 @default.
• W2045667028 cites W1980962702 @default.
• W2045667028 cites W1982220024 @default.
• W2045667028 cites W1986629865 @default.
• W2045667028 cites W1999830371 @default.
• W2045667028 cites W2001119540 @default.
• W2045667028 cites W2001277369 @default.
• W2045667028 cites W2006684770 @default.
• W2045667028 cites W2007008105 @default.
• W2045667028 cites W2007309361 @default.
• W2045667028 cites W2011807123 @default.
• W2045667028 cites W2014853910 @default.
• W2045667028 cites W2017196553 @default.
• W2045667028 cites W2019137326 @default.
• W2045667028 cites W2021534482 @default.
• W2045667028 cites W2027408247 @default.
• W2045667028 cites W2028231353 @default.
• W2045667028 cites W2028590095 @default.
• W2045667028 cites W2051436845 @default.
• W2045667028 cites W2061401901 @default.
• W2045667028 cites W2066039239 @default.
• W2045667028 cites W2070054675 @default.
• W2045667028 cites W2071280670 @default.
• W2045667028 cites W2075914095 @default.
• W2045667028 cites W2076223637 @default.
• W2045667028 cites W2079243965 @default.
• W2045667028 cites W2088409695 @default.
• W2045667028 cites W2093888439 @default.
• W2045667028 cites W2095050532 @default.
• W2045667028 cites W2095216354 @default.
• W2045667028 cites W2102537419 @default.
• W2045667028 cites W2107244464 @default.
• W2045667028 cites W2118044947 @default.
• W2045667028 cites W2127116852 @default.
• W2045667028 cites W2130347585 @default.
• W2045667028 cites W2146686098 @default.
• W2045667028 cites W2150310416 @default.
• W2045667028 cites W2157754272 @default.
• W2045667028 cites W2162166182 @default.
• W2045667028 cites W2170621128 @default.
• W2045667028 cites W3021991233 @default.
• W2045667028 cites W4242675968 @default.
• W2045667028 doi "https://doi.org/10.1021/ja003878z" @default.
• W2045667028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11414837" @default.
• W2045667028 hasPublicationYear "2001" @default.
• W2045667028 type Work @default.
• W2045667028 sameAs 2045667028 @default.
• W2045667028 citedByCount "47" @default.
• W2045667028 countsByYear W20456670282012 @default.
• W2045667028 countsByYear W20456670282013 @default.
• W2045667028 countsByYear W20456670282018 @default.
• W2045667028 countsByYear W20456670282021 @default.
• W2045667028 countsByYear W20456670282022 @default.
• W2045667028 countsByYear W20456670282023 @default.
• W2045667028 crossrefType "journal-article" @default.
• W2045667028 hasAuthorship W2045667028A5005741691 @default.
• W2045667028 hasAuthorship W2045667028A5020076636 @default.
• W2045667028 hasAuthorship W2045667028A5024132636 @default.
• W2045667028 hasAuthorship W2045667028A5043534314 @default.
• W2045667028 hasConcept C104292427 @default.
• W2045667028 hasConcept C104317684 @default.
• W2045667028 hasConcept C147597530 @default.
• W2045667028 hasConcept C178790620 @default.
• W2045667028 hasConcept C181199279 @default.
• W2045667028 hasConcept C185592680 @default.
• W2045667028 hasConcept C20705724 @default.
• W2045667028 hasConcept C2776217839 @default.
• W2045667028 hasConcept C2780768313 @default.
• W2045667028 hasConcept C28859421 @default.
• W2045667028 hasConcept C29311851 @default.
• W2045667028 hasConcept C55493867 @default.
• W2045667028 hasConcept C55904794 @default.
• W2045667028 hasConcept C59593255 @default.
• W2045667028 hasConcept C71240020 @default.
• W2045667028 hasConcept C8010536 @default.
• W2045667028 hasConceptScore W2045667028C104292427 @default.
• W2045667028 hasConceptScore W2045667028C104317684 @default.
• W2045667028 hasConceptScore W2045667028C147597530 @default.
• W2045667028 hasConceptScore W2045667028C178790620 @default.
• W2045667028 hasConceptScore W2045667028C181199279 @default.
• W2045667028 hasConceptScore W2045667028C185592680 @default.
• W2045667028 hasConceptScore W2045667028C20705724 @default.
• W2045667028 hasConceptScore W2045667028C2776217839 @default.
• W2045667028 hasConceptScore W2045667028C2780768313 @default.
• W2045667028 hasConceptScore W2045667028C28859421 @default.
• W2045667028 hasConceptScore W2045667028C29311851 @default.

• next