FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045668077> ?p ?o ?g. }

• W2045668077 endingPage "767" @default.
• W2045668077 startingPage "759" @default.
• W2045668077 abstract "To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in mycobacterial inflammation, IL-1 alpha/beta double-knockout (KO) mice were produced. These mice were infected with either Mycobacterium tuberculosis H37Rv by the airborne route using an airborne infection apparatus, and their capacities to control mycobacterial growth, granuloma formation, cytokine, and nitric oxide (NO) production were examined. The IL-1 alpha/beta mice developed significantly larger (p < 0.01) granulomatous, but not necrotic, lesions in their lungs than wild-type (WT) mice after infection with H37Rv. Inflammatory lesions, but not granulomas, were observed in spleen and liver tissues from both IL-1 alpha/beta KO and wild-type mice. Granulomatous lesion development in IL-1 alpha/beta KO mice was not significantly inhibited by treatment with exogenous recombinant IL-1 alpha/beta. Compared with wild-type mice, splenic IFN-gamma and IL-12 levels were within the normal range. NO production by cultured alveolar macrophages from IL-1 alpha/beta KO mice was lower than in wild-type mice but were increased by the addition of recombinant IL-1 alpha/beta. Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection." @default.
• W2045668077 created "2016-06-24" @default.
• W2045668077 creator A5011662582 @default.
• W2045668077 creator A5034002948 @default.
• W2045668077 creator A5037231222 @default.
• W2045668077 creator A5053096685 @default.
• W2045668077 creator A5074919264 @default.
• W2045668077 date "2000-05-01" @default.
• W2045668077 modified "2023-10-18" @default.
• W2045668077 title "Protective Role of Interleukin-1 in Mycobacterial Infection in IL-1 α/β Double-Knockout Mice" @default.
• W2045668077 cites W1515994079 @default.
• W2045668077 cites W1566128266 @default.
• W2045668077 cites W1896675849 @default.
• W2045668077 cites W1942463334 @default.
• W2045668077 cites W1966411920 @default.
• W2045668077 cites W2024418426 @default.
• W2045668077 cites W2043969727 @default.
• W2045668077 cites W2053067638 @default.
• W2045668077 cites W2086545085 @default.
• W2045668077 cites W2089262366 @default.
• W2045668077 cites W2099499236 @default.
• W2045668077 cites W2109484445 @default.
• W2045668077 cites W2111045447 @default.
• W2045668077 cites W2115587787 @default.
• W2045668077 cites W2130046741 @default.
• W2045668077 cites W2151738661 @default.
• W2045668077 cites W2153365712 @default.
• W2045668077 cites W2171231066 @default.
• W2045668077 doi "https://doi.org/10.1038/labinvest.3780079" @default.
• W2045668077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10830786" @default.
• W2045668077 hasPublicationYear "2000" @default.
• W2045668077 type Work @default.
• W2045668077 sameAs 2045668077 @default.
• W2045668077 citedByCount "192" @default.
• W2045668077 countsByYear W20456680772012 @default.
• W2045668077 countsByYear W20456680772013 @default.
• W2045668077 countsByYear W20456680772014 @default.
• W2045668077 countsByYear W20456680772015 @default.
• W2045668077 countsByYear W20456680772016 @default.
• W2045668077 countsByYear W20456680772017 @default.
• W2045668077 countsByYear W20456680772018 @default.
• W2045668077 countsByYear W20456680772019 @default.
• W2045668077 countsByYear W20456680772020 @default.
• W2045668077 countsByYear W20456680772021 @default.
• W2045668077 countsByYear W20456680772022 @default.
• W2045668077 countsByYear W20456680772023 @default.
• W2045668077 crossrefType "journal-article" @default.
• W2045668077 hasAuthorship W2045668077A5011662582 @default.
• W2045668077 hasAuthorship W2045668077A5034002948 @default.
• W2045668077 hasAuthorship W2045668077A5037231222 @default.
• W2045668077 hasAuthorship W2045668077A5053096685 @default.
• W2045668077 hasAuthorship W2045668077A5074919264 @default.
• W2045668077 hasBestOaLocation W20456680771 @default.
• W2045668077 hasConcept C142724271 @default.
• W2045668077 hasConcept C159110408 @default.
• W2045668077 hasConcept C164027704 @default.
• W2045668077 hasConcept C191732599 @default.
• W2045668077 hasConcept C199360897 @default.
• W2045668077 hasConcept C203014093 @default.
• W2045668077 hasConcept C2775944032 @default.
• W2045668077 hasConcept C2776174256 @default.
• W2045668077 hasConcept C2776914184 @default.
• W2045668077 hasConcept C2778690821 @default.
• W2045668077 hasConcept C2780140890 @default.
• W2045668077 hasConcept C2780931953 @default.
• W2045668077 hasConcept C41008148 @default.
• W2045668077 hasConcept C49453240 @default.
• W2045668077 hasConcept C64943373 @default.
• W2045668077 hasConcept C71924100 @default.
• W2045668077 hasConcept C74172505 @default.
• W2045668077 hasConcept C86803240 @default.
• W2045668077 hasConceptScore W2045668077C142724271 @default.
• W2045668077 hasConceptScore W2045668077C159110408 @default.
• W2045668077 hasConceptScore W2045668077C164027704 @default.
• W2045668077 hasConceptScore W2045668077C191732599 @default.
• W2045668077 hasConceptScore W2045668077C199360897 @default.
• W2045668077 hasConceptScore W2045668077C203014093 @default.
• W2045668077 hasConceptScore W2045668077C2775944032 @default.
• W2045668077 hasConceptScore W2045668077C2776174256 @default.
• W2045668077 hasConceptScore W2045668077C2776914184 @default.
• W2045668077 hasConceptScore W2045668077C2778690821 @default.
• W2045668077 hasConceptScore W2045668077C2780140890 @default.
• W2045668077 hasConceptScore W2045668077C2780931953 @default.
• W2045668077 hasConceptScore W2045668077C41008148 @default.
• W2045668077 hasConceptScore W2045668077C49453240 @default.
• W2045668077 hasConceptScore W2045668077C64943373 @default.
• W2045668077 hasConceptScore W2045668077C71924100 @default.
• W2045668077 hasConceptScore W2045668077C74172505 @default.
• W2045668077 hasConceptScore W2045668077C86803240 @default.
• W2045668077 hasIssue "5" @default.
• W2045668077 hasLocation W20456680771 @default.
• W2045668077 hasLocation W20456680772 @default.
• W2045668077 hasOpenAccess W2045668077 @default.
• W2045668077 hasPrimaryLocation W20456680771 @default.
• W2045668077 hasRelatedWork W2011513035 @default.
• W2045668077 hasRelatedWork W2090717967 @default.
• W2045668077 hasRelatedWork W2120522249 @default.
• W2045668077 hasRelatedWork W2137283203 @default.

• next