FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045669641> ?p ?o ?g. }

• W2045669641 endingPage "104" @default.
• W2045669641 startingPage "99" @default.
• W2045669641 abstract "The blood-brain barrier (BBB) is formed by the presence of tight junction complexes between brain endothelial cells that restrict paracellular permeability. As a consequence, a number of transport proteins are expressed on cerebral endothelial cells to facilitate the transport of nutrients into the brain. Although the modulation of barrier tight junction properties by glial-conditioned medium and by second messengers is well established, little is known about the effects of these factors on carrier-mediated BBB transport processes. The ECV304 cell line shows an endothelial phenotype and can be induced to upregulate certain BBB features in the presence of glial factors. In the present study, we have examined the effect of conditioned medium derived from rat C6-glioma cells (C6CM) on the function of the L-system amino acid transporter in ECV304 cells, using L-leucine as the model substrate, and have determined whether the changes observed can be mimicked by modulating intracellular cAMP levels. ECV304 cells exposed to C6CM exhibited a significant increase in both the affinity of leucine transport and the diffusional constant (Michaelis-Menten), while the maximal transport capacity remained unchanged. Conversely, acute exposure to modulators of the PKA and PKC second messenger pathways was found to reduce significantly the maximal transport capacity and diffusion constants, while transport affinity remained unchanged. In both cases, the maximal flux of leucine was increased, indicating transport of greater efficiency. This study indicates that exposure of ECV304 cells to C6CM provides an influence inducing L-system transport properties characteristic of brain endothelial cells. Furthermore, it appears that L-system-mediated transport of amino acids can be modulated by several distinct pathways." @default.
• W2045669641 created "2016-06-24" @default.
• W2045669641 creator A5009295861 @default.
• W2045669641 creator A5050129474 @default.
• W2045669641 creator A5071494174 @default.
• W2045669641 creator A5087712270 @default.
• W2045669641 date "2002-05-21" @default.
• W2045669641 modified "2023-10-10" @default.
• W2045669641 title "Glial induction of blood-brain barrier-Like L-system amino acid transport in the ECV304 cell line" @default.
• W2045669641 cites W168401264 @default.
• W2045669641 cites W1920778929 @default.
• W2045669641 cites W1970539529 @default.
• W2045669641 cites W1976192790 @default.
• W2045669641 cites W1984711181 @default.
• W2045669641 cites W1986071376 @default.
• W2045669641 cites W1986113285 @default.
• W2045669641 cites W1990104488 @default.
• W2045669641 cites W2000334988 @default.
• W2045669641 cites W2003627673 @default.
• W2045669641 cites W2005447528 @default.
• W2045669641 cites W2007494885 @default.
• W2045669641 cites W2009734677 @default.
• W2045669641 cites W2010603453 @default.
• W2045669641 cites W2017017806 @default.
• W2045669641 cites W2023832715 @default.
• W2045669641 cites W2025688358 @default.
• W2045669641 cites W2039206383 @default.
• W2045669641 cites W2049429481 @default.
• W2045669641 cites W2055137108 @default.
• W2045669641 cites W2056115953 @default.
• W2045669641 cites W2063991043 @default.
• W2045669641 cites W2070784200 @default.
• W2045669641 cites W2081868313 @default.
• W2045669641 cites W2087803534 @default.
• W2045669641 cites W2113634953 @default.
• W2045669641 cites W2118309500 @default.
• W2045669641 cites W2129843133 @default.
• W2045669641 cites W2152353759 @default.
• W2045669641 cites W2152525754 @default.
• W2045669641 cites W2186211825 @default.
• W2045669641 cites W2325226573 @default.
• W2045669641 cites W2339629532 @default.
• W2045669641 cites W2398316679 @default.
• W2045669641 cites W2497779636 @default.
• W2045669641 cites W57616982 @default.
• W2045669641 cites W2067301137 @default.
• W2045669641 doi "https://doi.org/10.1002/glia.10090" @default.
• W2045669641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12112361" @default.
• W2045669641 hasPublicationYear "2002" @default.
• W2045669641 type Work @default.
• W2045669641 sameAs 2045669641 @default.
• W2045669641 citedByCount "11" @default.
• W2045669641 countsByYear W20456696412012 @default.
• W2045669641 countsByYear W20456696412018 @default.
• W2045669641 crossrefType "journal-article" @default.
• W2045669641 hasAuthorship W2045669641A5009295861 @default.
• W2045669641 hasAuthorship W2045669641A5050129474 @default.
• W2045669641 hasAuthorship W2045669641A5071494174 @default.
• W2045669641 hasAuthorship W2045669641A5087712270 @default.
• W2045669641 hasConcept C104317684 @default.
• W2045669641 hasConcept C120882062 @default.
• W2045669641 hasConcept C123012128 @default.
• W2045669641 hasConcept C12554922 @default.
• W2045669641 hasConcept C134018914 @default.
• W2045669641 hasConcept C149011108 @default.
• W2045669641 hasConcept C177779419 @default.
• W2045669641 hasConcept C202751555 @default.
• W2045669641 hasConcept C2778402981 @default.
• W2045669641 hasConcept C41625074 @default.
• W2045669641 hasConcept C529278444 @default.
• W2045669641 hasConcept C55493867 @default.
• W2045669641 hasConcept C60903277 @default.
• W2045669641 hasConcept C79879829 @default.
• W2045669641 hasConcept C86803240 @default.
• W2045669641 hasConcept C95444343 @default.
• W2045669641 hasConceptScore W2045669641C104317684 @default.
• W2045669641 hasConceptScore W2045669641C120882062 @default.
• W2045669641 hasConceptScore W2045669641C123012128 @default.
• W2045669641 hasConceptScore W2045669641C12554922 @default.
• W2045669641 hasConceptScore W2045669641C134018914 @default.
• W2045669641 hasConceptScore W2045669641C149011108 @default.
• W2045669641 hasConceptScore W2045669641C177779419 @default.
• W2045669641 hasConceptScore W2045669641C202751555 @default.
• W2045669641 hasConceptScore W2045669641C2778402981 @default.
• W2045669641 hasConceptScore W2045669641C41625074 @default.
• W2045669641 hasConceptScore W2045669641C529278444 @default.
• W2045669641 hasConceptScore W2045669641C55493867 @default.
• W2045669641 hasConceptScore W2045669641C60903277 @default.
• W2045669641 hasConceptScore W2045669641C79879829 @default.
• W2045669641 hasConceptScore W2045669641C86803240 @default.
• W2045669641 hasConceptScore W2045669641C95444343 @default.
• W2045669641 hasIssue "2" @default.
• W2045669641 hasLocation W20456696411 @default.
• W2045669641 hasLocation W20456696412 @default.
• W2045669641 hasOpenAccess W2045669641 @default.
• W2045669641 hasPrimaryLocation W20456696411 @default.
• W2045669641 hasRelatedWork W1729818254 @default.
• W2045669641 hasRelatedWork W2003445994 @default.

• next