FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045672110> ?p ?o ?g. }

• W2045672110 endingPage "8307" @default.
• W2045672110 startingPage "8297" @default.
• W2045672110 abstract "Although capsular polysaccharide (CPS) is critical for meningococcal virulence, the molecular basis of alternative complement pathway (AP) regulation by meningococcal CPSs remains unclear. Using serum with only the AP active, the ability of strains to generate C3a (a measure of C3 activation) and subsequently deposit C3 fragments on bacteria was studied in encapsulated group A, B, C, W-135, and Y strains and their isogenic unencapsulated mutants. To eliminate confounding AP regulation by membrane-bound factor H (fH; AP inhibitor) and lipooligosaccharide sialic acid, the meningococcal fH ligands (fHbp and NspA) and lipooligosaccharide sialylation were deleted in all strains. Group A CPS expression did not affect C3a generation or C3 deposition. C3a generated by encapsulated and unencapsulated group B and C strains was similar, but CPS expression was associated with reduced C3 deposition, suggesting that these CPSs blocked C3 deposition on membrane targets. Paradoxically, encapsulated W-135 and Y strains (including the wild-type parent strains) enhanced C3 activation and showed marked C3 deposition as early as 10 min; at this time point C3 was barely activated by the unencapsulated mutants. W-135 and Y CPSs themselves served as a site for C3 deposition; this observation was confirmed using immobilized purified CPSs. Purified CPSs bound to unencapsulated meningococci, simulated findings with naturally encapsulated strains. These data highlight the heterogeneity of AP activation on the various meningococcal serogroups that may contribute to differences in their pathogenic mechanisms." @default.
• W2045672110 created "2016-06-24" @default.
• W2045672110 creator A5027901266 @default.
• W2045672110 creator A5041628441 @default.
• W2045672110 creator A5089695874 @default.
• W2045672110 date "2011-03-01" @default.
• W2045672110 modified "2023-10-12" @default.
• W2045672110 title "Meningococcal Group W-135 and Y Capsular Polysaccharides Paradoxically Enhance Activation of the Alternative Pathway of Complement" @default.
• W2045672110 cites W1253835855 @default.
• W2045672110 cites W1493695134 @default.
• W2045672110 cites W1526898493 @default.
• W2045672110 cites W1549655094 @default.
• W2045672110 cites W1573537338 @default.
• W2045672110 cites W1574987843 @default.
• W2045672110 cites W1617711359 @default.
• W2045672110 cites W1915040721 @default.
• W2045672110 cites W1917615343 @default.
• W2045672110 cites W1970276449 @default.
• W2045672110 cites W1976147464 @default.
• W2045672110 cites W1977837863 @default.
• W2045672110 cites W1986528054 @default.
• W2045672110 cites W1988910740 @default.
• W2045672110 cites W1989222495 @default.
• W2045672110 cites W1992234010 @default.
• W2045672110 cites W1992548028 @default.
• W2045672110 cites W1996075092 @default.
• W2045672110 cites W2004510339 @default.
• W2045672110 cites W2006207130 @default.
• W2045672110 cites W2011733924 @default.
• W2045672110 cites W2018063325 @default.
• W2045672110 cites W2018831327 @default.
• W2045672110 cites W2023355522 @default.
• W2045672110 cites W2041019262 @default.
• W2045672110 cites W2042425014 @default.
• W2045672110 cites W2045676546 @default.
• W2045672110 cites W2046413430 @default.
• W2045672110 cites W2047310221 @default.
• W2045672110 cites W2057333152 @default.
• W2045672110 cites W2073775604 @default.
• W2045672110 cites W2082062394 @default.
• W2045672110 cites W2082309459 @default.
• W2045672110 cites W2097250023 @default.
• W2045672110 cites W2100357361 @default.
• W2045672110 cites W2100398762 @default.
• W2045672110 cites W2102537411 @default.
• W2045672110 cites W2104984659 @default.
• W2045672110 cites W2105380293 @default.
• W2045672110 cites W2107179227 @default.
• W2045672110 cites W2108177341 @default.
• W2045672110 cites W2108401758 @default.
• W2045672110 cites W2119308622 @default.
• W2045672110 cites W2123881608 @default.
• W2045672110 cites W2127109116 @default.
• W2045672110 cites W2127157242 @default.
• W2045672110 cites W2137966873 @default.
• W2045672110 cites W2138450775 @default.
• W2045672110 cites W2146119268 @default.
• W2045672110 cites W2147711127 @default.
• W2045672110 cites W2153694943 @default.
• W2045672110 cites W2155127516 @default.
• W2045672110 cites W2157980489 @default.
• W2045672110 cites W2159414270 @default.
• W2045672110 cites W2166663556 @default.
• W2045672110 cites W2169875502 @default.
• W2045672110 cites W2250068495 @default.
• W2045672110 cites W315197452 @default.
• W2045672110 cites W4234783518 @default.
• W2045672110 cites W4241342138 @default.
• W2045672110 cites W4245890487 @default.
• W2045672110 cites W98488531 @default.
• W2045672110 doi "https://doi.org/10.1074/jbc.m110.184838" @default.
• W2045672110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3048715" @default.
• W2045672110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21245150" @default.
• W2045672110 hasPublicationYear "2011" @default.
• W2045672110 type Work @default.
• W2045672110 sameAs 2045672110 @default.
• W2045672110 citedByCount "31" @default.
• W2045672110 countsByYear W20456721102012 @default.
• W2045672110 countsByYear W20456721102013 @default.
• W2045672110 countsByYear W20456721102014 @default.
• W2045672110 countsByYear W20456721102015 @default.
• W2045672110 countsByYear W20456721102016 @default.
• W2045672110 countsByYear W20456721102017 @default.
• W2045672110 countsByYear W20456721102019 @default.
• W2045672110 countsByYear W20456721102020 @default.
• W2045672110 countsByYear W20456721102022 @default.
• W2045672110 crossrefType "journal-article" @default.
• W2045672110 hasAuthorship W2045672110A5027901266 @default.
• W2045672110 hasAuthorship W2045672110A5041628441 @default.
• W2045672110 hasAuthorship W2045672110A5089695874 @default.
• W2045672110 hasBestOaLocation W20456721101 @default.
• W2045672110 hasConcept C100817775 @default.
• W2045672110 hasConcept C104317684 @default.
• W2045672110 hasConcept C111684460 @default.
• W2045672110 hasConcept C118687296 @default.
• W2045672110 hasConcept C126322002 @default.
• W2045672110 hasConcept C143065580 @default.
• W2045672110 hasConcept C146587185 @default.

• next