FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045674295> ?p ?o ?g. }

• W2045674295 endingPage "1449" @default.
• W2045674295 startingPage "1439" @default.
• W2045674295 abstract "Wound infection is a complication feared in surgery. The aim of this study was to develop new anti-infective coatings of surgical sutures and to compare the anti-microbial effectiveness and biocompatibility to the well-established Vicryl Plus. Synthetic absorbable PGA surgical sutures were coated with three different chlorhexidine concentrations and two different octenidine concentrations in combination with palmitic acid and lauric acid. Drug-release kinetics lasting 96 h were studied in phosphate-buffered saline at 37 degrees C. Anti-infective characteristics were determined by measuring the change in optical density of Staphylococcus aureus suspensions charged with coated sutures over time. Microorganisms adsorbed at the surface of coated sutures were assessed on blood agar plates and coated sutures eluted for 24 h were placed on bacterial lawns cultured on Mueller-Hinton plates to prove retained anti-microbial potency. A cell proliferation assay was performed to assess the degree of cytotoxicity. Anti-infective characteristics and biocompatibility were compared to Vicryl Plus. A coating technology for slow-release drug-delivery systems on surgical sutures could be developed. All coatings showed a continuous drug release within 96 h. Individual chlorhexidine and octenidine coated sutures showed superior anti-infective characteristics but inferior biocompatibility in comparison to Vicryl Plus. We conclude that the developed anti-infective suture coatings consisting of lipid-based drug-delivery systems in combination with antiseptics are highly effective against bacterial colonization in vitro; however, drug doses have to be adjusted to improve biocompatibility." @default.
• W2045674295 created "2016-06-24" @default.
• W2045674295 creator A5012624684 @default.
• W2045674295 creator A5016601141 @default.
• W2045674295 creator A5032284865 @default.
• W2045674295 creator A5034380645 @default.
• W2045674295 creator A5047972666 @default.
• W2045674295 creator A5059422622 @default.
• W2045674295 creator A5074794578 @default.
• W2045674295 creator A5077618118 @default.
• W2045674295 creator A5078204753 @default.
• W2045674295 date "2009-01-01" @default.
• W2045674295 modified "2023-09-24" @default.
• W2045674295 title "New Anti-infective Coatings of Surgical Sutures Based on a Combination of Antiseptics and Fatty Acids" @default.
• W2045674295 cites W1493879424 @default.
• W2045674295 cites W1505656648 @default.
• W2045674295 cites W1842787690 @default.
• W2045674295 cites W1914163089 @default.
• W2045674295 cites W1966690336 @default.
• W2045674295 cites W1986302632 @default.
• W2045674295 cites W1998247013 @default.
• W2045674295 cites W2003808881 @default.
• W2045674295 cites W2010320086 @default.
• W2045674295 cites W2026787937 @default.
• W2045674295 cites W2065103628 @default.
• W2045674295 cites W2066941250 @default.
• W2045674295 cites W2091283451 @default.
• W2045674295 cites W2092744085 @default.
• W2045674295 cites W2095381655 @default.
• W2045674295 cites W2103743650 @default.
• W2045674295 cites W2109261030 @default.
• W2045674295 cites W2111074810 @default.
• W2045674295 cites W2115135671 @default.
• W2045674295 cites W2134918371 @default.
• W2045674295 cites W2136487020 @default.
• W2045674295 cites W2156297153 @default.
• W2045674295 cites W2157266521 @default.
• W2045674295 cites W4250032087 @default.
• W2045674295 cites W49894026 @default.
• W2045674295 doi "https://doi.org/10.1163/092050609x12457418973107" @default.
• W2045674295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19622281" @default.
• W2045674295 hasPublicationYear "2009" @default.
• W2045674295 type Work @default.
• W2045674295 sameAs 2045674295 @default.
• W2045674295 citedByCount "39" @default.
• W2045674295 countsByYear W20456742952012 @default.
• W2045674295 countsByYear W20456742952013 @default.
• W2045674295 countsByYear W20456742952014 @default.
• W2045674295 countsByYear W20456742952015 @default.
• W2045674295 countsByYear W20456742952016 @default.
• W2045674295 countsByYear W20456742952017 @default.
• W2045674295 countsByYear W20456742952019 @default.
• W2045674295 countsByYear W20456742952020 @default.
• W2045674295 countsByYear W20456742952021 @default.
• W2045674295 countsByYear W20456742952022 @default.
• W2045674295 countsByYear W20456742952023 @default.
• W2045674295 crossrefType "journal-article" @default.
• W2045674295 hasAuthorship W2045674295A5012624684 @default.
• W2045674295 hasAuthorship W2045674295A5016601141 @default.
• W2045674295 hasAuthorship W2045674295A5032284865 @default.
• W2045674295 hasAuthorship W2045674295A5034380645 @default.
• W2045674295 hasAuthorship W2045674295A5047972666 @default.
• W2045674295 hasAuthorship W2045674295A5059422622 @default.
• W2045674295 hasAuthorship W2045674295A5074794578 @default.
• W2045674295 hasAuthorship W2045674295A5077618118 @default.
• W2045674295 hasAuthorship W2045674295A5078204753 @default.
• W2045674295 hasConcept C141071460 @default.
• W2045674295 hasConcept C178790620 @default.
• W2045674295 hasConcept C185592680 @default.
• W2045674295 hasConcept C199343813 @default.
• W2045674295 hasConcept C2776881634 @default.
• W2045674295 hasConcept C2777084678 @default.
• W2045674295 hasConcept C2777230088 @default.
• W2045674295 hasConcept C2777327002 @default.
• W2045674295 hasConcept C2779820397 @default.
• W2045674295 hasConcept C71924100 @default.
• W2045674295 hasConcept C86803240 @default.
• W2045674295 hasConcept C89423630 @default.
• W2045674295 hasConceptScore W2045674295C141071460 @default.
• W2045674295 hasConceptScore W2045674295C178790620 @default.
• W2045674295 hasConceptScore W2045674295C185592680 @default.
• W2045674295 hasConceptScore W2045674295C199343813 @default.
• W2045674295 hasConceptScore W2045674295C2776881634 @default.
• W2045674295 hasConceptScore W2045674295C2777084678 @default.
• W2045674295 hasConceptScore W2045674295C2777230088 @default.
• W2045674295 hasConceptScore W2045674295C2777327002 @default.
• W2045674295 hasConceptScore W2045674295C2779820397 @default.
• W2045674295 hasConceptScore W2045674295C71924100 @default.
• W2045674295 hasConceptScore W2045674295C86803240 @default.
• W2045674295 hasConceptScore W2045674295C89423630 @default.
• W2045674295 hasIssue "10" @default.
• W2045674295 hasLocation W20456742951 @default.
• W2045674295 hasLocation W20456742952 @default.
• W2045674295 hasOpenAccess W2045674295 @default.
• W2045674295 hasPrimaryLocation W20456742951 @default.
• W2045674295 hasRelatedWork W1608733658 @default.
• W2045674295 hasRelatedWork W1982665160 @default.
• W2045674295 hasRelatedWork W2056890527 @default.

• next