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• W2045675097 abstract "Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for centrosome duplication. In Caenorhabditis elegans embryos, the proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but the mechanisms underlying their requirement remain unclear. Here, we demonstrate that the kinase ZYG-1 phosphorylates the coiled-coil protein SAS-6 at serine 123 in vitro. Importantly, we show that this phosphorylation event is crucial for centriole formation in vivo. Furthermore, we establish that such phosphorylation ensures the maintenance of SAS-6 at the emerging centriole. Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division." @default.
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• W2045675097 date "2009-12-01" @default.
• W2045675097 modified "2023-10-03" @default.
• W2045675097 title "Phosphorylation of SAS-6 by ZYG-1 Is Critical for Centriole Formation in C. elegans Embryos" @default.
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• W2045675097 doi "https://doi.org/10.1016/j.devcel.2009.11.002" @default.
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