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• W2045678034 abstract "A parallel solid-phase synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones from MBHA resin is described. The reduction of resin-bound nitrosamino acids provides hydrazines efficiently without affecting the amide bond. The trityl protected hydrazine is then reduced with borane, and cyclized with 1,1-carbonyldiimidazole. The desired products are cleaved from their solid support and obtained in good yield and purity. This methodology is of value for the rapid parallel preparation of these potentially bioactive molecules." @default.
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• W2045678034 date "2013-06-13" @default.
• W2045678034 modified "2023-09-24" @default.
• W2045678034 title "Parallel Synthesis of 1,6-Disubstituted-1,2,4-triazin-3-ones on Solid-Phase" @default.
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• W2045678034 doi "https://doi.org/10.1021/co400064d" @default.
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