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- W2045679498 abstract "BACKGROUND The objective of this study was to evaluate the expression of platelet-derived growth factor (PDGF A, PDGF B) and their receptors (PDGF α, PDGF β) in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma. METHODS Peroxidase-antiperoxidase immunoperoxidase labeling was used to detect the extent of antibody labeling in 29 different high grade PIN specimens. RESULTS PDGF A and PDGF α were uniformly expressed in glandular epithelial and stromal cells, whereas PDGF B was not expressed by either tissue. However, PDGF β was lightly expressed in a uniform manner by both the glandular epithelial and stromal cells. CONCLUSIONS The data suggest that an autocrine loop may exist in which the epithelial cells of high-grade PIN express PDGF AA and PDGF α to modulate growth of precancerous lesions. © 1996 Wiley-Liss, Inc." @default.
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- W2045679498 date "1996-11-01" @default.
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- W2045679498 title "Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia" @default.
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- W2045679498 doi "https://doi.org/10.1002/(sici)1097-0045(199611)29:5<282::aid-pros2>3.0.co;2-c" @default.
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