Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045682875> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2045682875 endingPage "764" @default.
- W2045682875 startingPage "762" @default.
- W2045682875 abstract "The discovery by Takahashi and Yamanaka in 2006 that they could revert somatic cells to a pluripotent phenotype by overexpressing a limited number of defined reprogramming factors [1] has had a major impact on the stem cell research community. These so-called induced pluripotent stem (iPS) cells are very similar to embryonic-derived stem cells (ESCs) with respect to gene expression profile, proliferation, and pluripotent differentiation potential. The relative simplicity of the reprogramming technique, coupled with the ethical superiority over ESCs and the potential to produce a ready supply of patient-specific autologous cells arguablymake iPS cells themost promising stem cell source for regenerative medicine. As yet, iPS cells have not reached the clinical setting, with several major issues hindering translation. Foremost is the issue of safety arising from the introduction of potential oncogenes during the reprogramming process; this danger is clearly illustrated in the inherent capacity to form teratomas in vivo. Another issue is the unmet need to harness the pluripotency of the iPS cell to direct the progeny along a specific lineage or differentiation pathway to form a fully functional target tissue or organ. In this issue of European Urology, Moad and colleagues present their work showing, for the first time, the successful reprogramming of fibroblasts derived from prostate and urinary tract into iPS cells [2]. They achieve this by overexpressing the four Yamanaka transcription factors— POU5F1 (formerly OCT4A), SOX2, MYC, and KLF4—using a commercial lentivirus-based transduction system. The derivative stem cells were shown to be pluripotent, being able to form all three germ cell layers in vitro. Moad and colleagues nicely demonstrated the ability of their" @default.
- W2045682875 created "2016-06-24" @default.
- W2045682875 creator A5025375470 @default.
- W2045682875 creator A5053117144 @default.
- W2045682875 date "2013-11-01" @default.
- W2045682875 modified "2023-09-24" @default.
- W2045682875 title "Reprogramming Stromal Cells from the Urinary Tract and Prostate: A Trip to Pluripotency and Back?" @default.
- W2045682875 cites W1930929720 @default.
- W2045682875 cites W1972334415 @default.
- W2045682875 cites W1972431666 @default.
- W2045682875 cites W2037645142 @default.
- W2045682875 cites W2047824477 @default.
- W2045682875 cites W2059291562 @default.
- W2045682875 cites W2062416026 @default.
- W2045682875 cites W2070147440 @default.
- W2045682875 cites W2094166407 @default.
- W2045682875 cites W2125987139 @default.
- W2045682875 cites W2153834107 @default.
- W2045682875 doi "https://doi.org/10.1016/j.eururo.2013.05.018" @default.
- W2045682875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23706568" @default.
- W2045682875 hasPublicationYear "2013" @default.
- W2045682875 type Work @default.
- W2045682875 sameAs 2045682875 @default.
- W2045682875 citedByCount "5" @default.
- W2045682875 countsByYear W20456828752013 @default.
- W2045682875 countsByYear W20456828752014 @default.
- W2045682875 countsByYear W20456828752017 @default.
- W2045682875 countsByYear W20456828752019 @default.
- W2045682875 countsByYear W20456828752020 @default.
- W2045682875 crossrefType "journal-article" @default.
- W2045682875 hasAuthorship W2045682875A5025375470 @default.
- W2045682875 hasAuthorship W2045682875A5053117144 @default.
- W2045682875 hasConcept C121608353 @default.
- W2045682875 hasConcept C126322002 @default.
- W2045682875 hasConcept C126894567 @default.
- W2045682875 hasConcept C142724271 @default.
- W2045682875 hasConcept C1491633281 @default.
- W2045682875 hasConcept C16930146 @default.
- W2045682875 hasConcept C2776235491 @default.
- W2045682875 hasConcept C54355233 @default.
- W2045682875 hasConcept C71924100 @default.
- W2045682875 hasConcept C77255625 @default.
- W2045682875 hasConcept C77411442 @default.
- W2045682875 hasConcept C86803240 @default.
- W2045682875 hasConceptScore W2045682875C121608353 @default.
- W2045682875 hasConceptScore W2045682875C126322002 @default.
- W2045682875 hasConceptScore W2045682875C126894567 @default.
- W2045682875 hasConceptScore W2045682875C142724271 @default.
- W2045682875 hasConceptScore W2045682875C1491633281 @default.
- W2045682875 hasConceptScore W2045682875C16930146 @default.
- W2045682875 hasConceptScore W2045682875C2776235491 @default.
- W2045682875 hasConceptScore W2045682875C54355233 @default.
- W2045682875 hasConceptScore W2045682875C71924100 @default.
- W2045682875 hasConceptScore W2045682875C77255625 @default.
- W2045682875 hasConceptScore W2045682875C77411442 @default.
- W2045682875 hasConceptScore W2045682875C86803240 @default.
- W2045682875 hasIssue "5" @default.
- W2045682875 hasLocation W20456828751 @default.
- W2045682875 hasLocation W20456828752 @default.
- W2045682875 hasOpenAccess W2045682875 @default.
- W2045682875 hasPrimaryLocation W20456828751 @default.
- W2045682875 hasRelatedWork W2033525850 @default.
- W2045682875 hasRelatedWork W2049396222 @default.
- W2045682875 hasRelatedWork W2392413698 @default.
- W2045682875 hasRelatedWork W2395597204 @default.
- W2045682875 hasRelatedWork W2412574627 @default.
- W2045682875 hasRelatedWork W2517659937 @default.
- W2045682875 hasRelatedWork W2534571998 @default.
- W2045682875 hasRelatedWork W2789567460 @default.
- W2045682875 hasRelatedWork W3030894741 @default.
- W2045682875 hasRelatedWork W4288392727 @default.
- W2045682875 hasVolume "64" @default.
- W2045682875 isParatext "false" @default.
- W2045682875 isRetracted "false" @default.
- W2045682875 magId "2045682875" @default.
- W2045682875 workType "article" @default.