FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045683532> ?p ?o ?g. }

• W2045683532 endingPage "589" @default.
• W2045683532 startingPage "579" @default.
• W2045683532 abstract "The central nervous system (CNS) is an immunologically privileged site to which access of circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see Glossary) localized in CNS microvessels, and the epithelial blood–cerebrospinal fluid barrier (BCSFB) within the choroid plexus. As a result of the specialized structure of the CNS barriers, immune cell entry into the CNS parenchyma involves two differently regulated steps: migration of immune cells across the BBB or BCSFB into the cerebrospinal fluid (CSF)-drained spaces of the CNS, followed by progression across the glia limitans into the CNS parenchyma. With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers. The central nervous system (CNS) is an immunologically privileged site to which access of circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see Glossary) localized in CNS microvessels, and the epithelial blood–cerebrospinal fluid barrier (BCSFB) within the choroid plexus. As a result of the specialized structure of the CNS barriers, immune cell entry into the CNS parenchyma involves two differently regulated steps: migration of immune cells across the BBB or BCSFB into the cerebrospinal fluid (CSF)-drained spaces of the CNS, followed by progression across the glia limitans into the CNS parenchyma. With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers. a subtype of ectodermal derived glial cells in the CNS characterized by many foot-like processes interacting with neurons and embracing the abluminal aspect of CNS microvessels. a diffusion barrier formed by the unique cellular and molecular characteristics of endothelial cells and the glia limitans perivascularis of the microvessels in the CNS parenchyma. At the level of CNS capillaries, the BBB forms a direct barrier. a diffusion barrier formed by the epithelial cells of the choroid plexus localized in the ventricles of the brain. a diffusion barrier formed by the unique cellular and molecular characteristics of endothelial cells of the leptomeningeal microvessels at the surface of the brain and spinal cord. Strictly speaking, the BLMB forms a blood–CSF barrier. a highly vascularized and branched villous structure developing as a protuberance from the ependymal cells lining the brain ventricles. On the outside, the choroid plexus is lined by epithelial cells involved in the production of CSF. a sieve like structure within the ethmoid bone which separates the nasal cavity from the skull cavity. composed of the parenchymal basement membrane and astrocyte foot processes and covers the entire surface of the brain and spinal cord on external surfaces towards the leptomeningeal/subarachnoid space (glia limitans superficialis) and internally towards the perivascular spaces (glia limitans perivascularis). CSF-drained space at the surface of the CNS that protects and cushions the brain and spinal cord. This space is bordered on the outside by the arachnoid mater and towards the CNS parenchyma by the pia mater. Blood vessels at the surface of the CNS are localized in this space. migration of cells in between endothelial or epithelial cells including transient opening of their cellular junctions. vascular mural cell embedded within the endothelial basement membrane of blood microvessels. migration of cells through endothelial or epithelial cells forming a pore through the cell body." @default.
• W2045683532 created "2016-06-24" @default.
• W2045683532 creator A5034732141 @default.
• W2045683532 creator A5069271331 @default.
• W2045683532 date "2012-12-01" @default.
• W2045683532 modified "2023-10-12" @default.
• W2045683532 title "Capture, crawl, cross: the T cell code to breach the blood–brain barriers" @default.
• W2045683532 cites W1500346549 @default.
• W2045683532 cites W1514064771 @default.
• W2045683532 cites W1516653822 @default.
• W2045683532 cites W15977723 @default.
• W2045683532 cites W1650463686 @default.
• W2045683532 cites W1791569952 @default.
• W2045683532 cites W1948291240 @default.
• W2045683532 cites W1957559733 @default.
• W2045683532 cites W1960336193 @default.
• W2045683532 cites W1964134808 @default.
• W2045683532 cites W1968570285 @default.
• W2045683532 cites W1969766605 @default.
• W2045683532 cites W1973000903 @default.
• W2045683532 cites W1973763077 @default.
• W2045683532 cites W1974941387 @default.
• W2045683532 cites W1984589943 @default.
• W2045683532 cites W1985211443 @default.
• W2045683532 cites W1989528460 @default.
• W2045683532 cites W1990565111 @default.
• W2045683532 cites W1991884672 @default.
• W2045683532 cites W1993746949 @default.
• W2045683532 cites W1996722399 @default.
• W2045683532 cites W2001535098 @default.
• W2045683532 cites W2005701667 @default.
• W2045683532 cites W2006486528 @default.
• W2045683532 cites W2008680091 @default.
• W2045683532 cites W2009355727 @default.
• W2045683532 cites W2012912989 @default.
• W2045683532 cites W2013517841 @default.
• W2045683532 cites W2017830994 @default.
• W2045683532 cites W2020319641 @default.
• W2045683532 cites W2021988159 @default.
• W2045683532 cites W2031924346 @default.
• W2045683532 cites W2032432537 @default.
• W2045683532 cites W2034781062 @default.
• W2045683532 cites W2041264117 @default.
• W2045683532 cites W2045454822 @default.
• W2045683532 cites W2047575104 @default.
• W2045683532 cites W2051709074 @default.
• W2045683532 cites W2053313675 @default.
• W2045683532 cites W2060844162 @default.
• W2045683532 cites W2067810471 @default.
• W2045683532 cites W2074281049 @default.
• W2045683532 cites W2074295723 @default.
• W2045683532 cites W2078840769 @default.
• W2045683532 cites W2086235904 @default.
• W2045683532 cites W2086943873 @default.
• W2045683532 cites W2087402752 @default.
• W2045683532 cites W2092002465 @default.
• W2045683532 cites W2093363945 @default.
• W2045683532 cites W2111800376 @default.
• W2045683532 cites W2113948549 @default.
• W2045683532 cites W2116060589 @default.
• W2045683532 cites W2116491528 @default.
• W2045683532 cites W2119839841 @default.
• W2045683532 cites W2120862613 @default.
• W2045683532 cites W2127198284 @default.
• W2045683532 cites W2127471055 @default.
• W2045683532 cites W2130277789 @default.
• W2045683532 cites W2140427402 @default.
• W2045683532 cites W2140691459 @default.
• W2045683532 cites W2146826575 @default.
• W2045683532 cites W2147592133 @default.
• W2045683532 cites W2152719134 @default.
• W2045683532 cites W2152765608 @default.
• W2045683532 cites W2154793195 @default.
• W2045683532 cites W2155093913 @default.
• W2045683532 cites W2155492240 @default.
• W2045683532 cites W2159252214 @default.
• W2045683532 cites W2161766823 @default.
• W2045683532 cites W2165756416 @default.
• W2045683532 cites W2166769371 @default.
• W2045683532 cites W2291957309 @default.
• W2045683532 cites W2338797839 @default.
• W2045683532 cites W40284305 @default.
• W2045683532 cites W4242267807 @default.
• W2045683532 doi "https://doi.org/10.1016/j.it.2012.07.004" @default.
• W2045683532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22926201" @default.
• W2045683532 hasPublicationYear "2012" @default.
• W2045683532 type Work @default.
• W2045683532 sameAs 2045683532 @default.
• W2045683532 citedByCount "489" @default.
• W2045683532 countsByYear W20456835322013 @default.
• W2045683532 countsByYear W20456835322014 @default.
• W2045683532 countsByYear W20456835322015 @default.
• W2045683532 countsByYear W20456835322016 @default.
• W2045683532 countsByYear W20456835322017 @default.
• W2045683532 countsByYear W20456835322018 @default.
• W2045683532 countsByYear W20456835322019 @default.
• W2045683532 countsByYear W20456835322020 @default.
• W2045683532 countsByYear W20456835322021 @default.

• next