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• W2045685216 abstract "Abstract The cAMP content of cultured human fibroblasts was increased by incubation of the cells with choleragen, prostaglandin E1 (PGE1), or isoproterenol. Propranolol (80μM) markedly reduced the elevation in intracellular cAMP induced by choleragen or isoproterenol but increased the accumulation of cAMP secondary to PGE1. (“Propranolol”) refers to the racemic mixture; when either isomer alone was used, the appropriate designation is given.) Propranolol prolonged the delay in choleragen responsiveness, normally apparent in human fibroblasts; the effects of propranolol on choleragen and PGE1 occurred in the presence or absence of 3-isobutyl-l-methylxanthine and were observed on both intracellular and extracellular cAMP. d- and l-propranolol were equally effective with choleragen and PGE1, whereas l-propranolol was much more effective than d-propranolol in blocking the action of isoproterenol. Propranolol had no significant effect on the activation of adenylate cyclase by choleragen or PGE1. Butoxamine and dichloroisoproterenol did not decrease cAMP accumulation induced by choleragen but enhanced the response to PGE1. A lipid-soluble anesthetic, tetracaine, also increased the accumulation of intracellular cAMP due to PGE1 but inhibited the response to choleragen. These data indicate that propranolol exerts effects independent of its β-adrenergic blocking activity on agonist-induced changes in cAMP metabolism of human fibroblasts. In view of the concentrations of propranolol at which these “nonspecific” effects were observed, and based on similarities to actions of other drugs, it appears that some of the toxic and/or therapeutic effects of the drug may result from “membrane-stabilizing” properties and/or effects on microtubule assembly and may be unrelated to β-adrenergic blockade." @default.
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• W2045685216 title "Effects of d- and l-propranolol on the responsiveness of human fibroblasts to choleragen and prostaglandin E1" @default.
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• W2045685216 doi "https://doi.org/10.1016/0006-2952(81)90307-5" @default.
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