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- W2045686239 abstract "40 years after human parathyroid hormone (hPTH) was first synthesised by John Potts at the Massachusetts General Hospital in Boston, and more than 10 years after the US Food and Drug Administration approved recombinant PTH for the treatment of osteoporosis, 1 Neer RM Arnaud CD Zanchetta JR et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001; 344: 1434-1441 Crossref PubMed Scopus (3781) Google Scholar The Lancet Diabetes & Endocrinology report the results of Michael Mannstadt and colleagues' 2 Mannstadt M Clarke BL Vokes T et al. Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol. 2013; (published online Oct 7.)http://dx.doi.org/10.1016/S2213-8587(13)70106-2 Google Scholar study of the efficacy of recombinant hPTH (rhPTH) to treat hypoparathyroidism. Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study50 μg, 75 μg, or 100 μg per day of rhPTH(1–84), administered subcutaneously in the outpatient setting, is efficacious and well tolerated as a PTH replacement therapy for patients with hypoparathyroidism. Full-Text PDF" @default.
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- W2045686239 date "2013-12-01" @default.
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- W2045686239 title "From synthesis to replacement of parathyroid hormone" @default.
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- W2045686239 doi "https://doi.org/10.1016/s2213-8587(13)70145-1" @default.
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