FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045687308> ?p ?o ?g. }

• W2045687308 endingPage "4358" @default.
• W2045687308 startingPage "4345" @default.
• W2045687308 abstract "Linear chromosomes terminate in specialized nucleoprotein structures called telomeres, which are required for genomic stability and cellular proliferation. Telomeres end in an unusual 3′ single-strand overhang that requires a special capping mechanism to prevent inappropriate recognition by the DNA damage machinery. In Schizosaccharomyces pombe, this protective function is mediated by the Pot1 protein, which binds specifically and with high affinity to telomeric ssDNA. We have characterized the thermodynamics and accommodation of both cognate and noncognate telomeric single-stranded DNA (ssDNA) sequences by Pot1pN, an autonomous ssDNA-binding domain (residues 1–187) found in full-length S. pombe Pot1. Direct calorimetric measurements of cognate telomeric ssDNA binding to Pot1pN show favorable enthalpy, unfavorable entropy, and a negative heat-capacity change. Thermodynamic analysis of the binding of noncognate telomeric ssDNA to Pot1pN resulted in unexpected changes in free energy, enthalpy, and entropy. Chemical-shift perturbation and structural analysis of these bound noncognate sequences show that these thermodynamic changes result from the structural rearrangement of both Pot1pN and the bound oligonucleotide. These data suggest that the ssDNA-binding interface is highly dynamic and, in addition to the conformation observed in the crystal structure of the Pot1pN/d(GGTTAC) complex, capable of adopting alternative thermodynamically equivalent conformations." @default.
• W2045687308 created "2016-06-24" @default.
• W2045687308 creator A5029302725 @default.
• W2045687308 creator A5031343617 @default.
• W2045687308 creator A5037564973 @default.
• W2045687308 creator A5058645724 @default.
• W2045687308 date "2008-03-21" @default.
• W2045687308 modified "2023-10-18" @default.
• W2045687308 title "Deciphering the Mechanism of Thermodynamic Accommodation of Telomeric Oligonucleotide Sequences by the Schizosaccharomyces pombe Protection of Telomeres 1 (Pot1pN) Protein" @default.
• W2045687308 cites W1806123628 @default.
• W2045687308 cites W1964393554 @default.
• W2045687308 cites W1965127482 @default.
• W2045687308 cites W1966427711 @default.
• W2045687308 cites W1970434360 @default.
• W2045687308 cites W1977935196 @default.
• W2045687308 cites W1982224815 @default.
• W2045687308 cites W1983634771 @default.
• W2045687308 cites W1985798551 @default.
• W2045687308 cites W1986704394 @default.
• W2045687308 cites W1993948607 @default.
• W2045687308 cites W1995922973 @default.
• W2045687308 cites W2000050780 @default.
• W2045687308 cites W2011862425 @default.
• W2045687308 cites W2012218514 @default.
• W2045687308 cites W2015901138 @default.
• W2045687308 cites W2016831387 @default.
• W2045687308 cites W2017875807 @default.
• W2045687308 cites W2019163268 @default.
• W2045687308 cites W2027959847 @default.
• W2045687308 cites W2036400318 @default.
• W2045687308 cites W2036620149 @default.
• W2045687308 cites W2041579107 @default.
• W2045687308 cites W2044791372 @default.
• W2045687308 cites W2052650104 @default.
• W2045687308 cites W2053684353 @default.
• W2045687308 cites W2063465093 @default.
• W2045687308 cites W2074114182 @default.
• W2045687308 cites W2077020328 @default.
• W2045687308 cites W2080032853 @default.
• W2045687308 cites W2082308337 @default.
• W2045687308 cites W2082835279 @default.
• W2045687308 cites W2086095857 @default.
• W2045687308 cites W2090827678 @default.
• W2045687308 cites W2091832350 @default.
• W2045687308 cites W2093400164 @default.
• W2045687308 cites W2093847445 @default.
• W2045687308 cites W2094767232 @default.
• W2045687308 cites W2098173967 @default.
• W2045687308 cites W2099057076 @default.
• W2045687308 cites W2104017463 @default.
• W2045687308 cites W2105901498 @default.
• W2045687308 cites W2124325047 @default.
• W2045687308 cites W2143079801 @default.
• W2045687308 cites W2148521301 @default.
• W2045687308 cites W2159439902 @default.
• W2045687308 cites W2169707043 @default.
• W2045687308 cites W2169821755 @default.
• W2045687308 cites W2171810840 @default.
• W2045687308 doi "https://doi.org/10.1021/bi701778x" @default.
• W2045687308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3987967" @default.
• W2045687308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355038" @default.
• W2045687308 hasPublicationYear "2008" @default.
• W2045687308 type Work @default.
• W2045687308 sameAs 2045687308 @default.
• W2045687308 citedByCount "10" @default.
• W2045687308 countsByYear W20456873082012 @default.
• W2045687308 countsByYear W20456873082014 @default.
• W2045687308 countsByYear W20456873082015 @default.
• W2045687308 crossrefType "journal-article" @default.
• W2045687308 hasAuthorship W2045687308A5029302725 @default.
• W2045687308 hasAuthorship W2045687308A5031343617 @default.
• W2045687308 hasAuthorship W2045687308A5037564973 @default.
• W2045687308 hasAuthorship W2045687308A5058645724 @default.
• W2045687308 hasBestOaLocation W20456873082 @default.
• W2045687308 hasConcept C106301342 @default.
• W2045687308 hasConcept C121332964 @default.
• W2045687308 hasConcept C12554922 @default.
• W2045687308 hasConcept C129312508 @default.
• W2045687308 hasConcept C177336024 @default.
• W2045687308 hasConcept C185592680 @default.
• W2045687308 hasConcept C2776519988 @default.
• W2045687308 hasConcept C2777576037 @default.
• W2045687308 hasConcept C2779222958 @default.
• W2045687308 hasConcept C2779429346 @default.
• W2045687308 hasConcept C552990157 @default.
• W2045687308 hasConcept C55493867 @default.
• W2045687308 hasConcept C8010536 @default.
• W2045687308 hasConcept C86803240 @default.
• W2045687308 hasConcept C97355855 @default.
• W2045687308 hasConceptScore W2045687308C106301342 @default.
• W2045687308 hasConceptScore W2045687308C121332964 @default.
• W2045687308 hasConceptScore W2045687308C12554922 @default.
• W2045687308 hasConceptScore W2045687308C129312508 @default.
• W2045687308 hasConceptScore W2045687308C177336024 @default.
• W2045687308 hasConceptScore W2045687308C185592680 @default.
• W2045687308 hasConceptScore W2045687308C2776519988 @default.
• W2045687308 hasConceptScore W2045687308C2777576037 @default.
• W2045687308 hasConceptScore W2045687308C2779222958 @default.

• next