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• W2045687629 abstract "Although chemoradiation therapy (CRT) is widely used as a curative treatment for esophageal cancer (EC), little is known about safety and efficacy for elderly patients. The aim of this study is to investigate the tolerability and outcome of definitive CRT for elderly patients, here we defined older than 70 years old, with EC. We retrospectively reviewed 134 EC patients treated with definitive CRT at two institutions between 2008 and 2012. There were 51 elderly (over 70 years old) and 83 nonelderly (under 69 years old) patients. One patient had adenocarcinoma and 133 patients had squamous cell carcinoma. Clinical stages I/II/III/IV were 7/7/29/8 patients in the elderly and 14/16/33/20 patients in the nonelderly (UICC 6th). Radiation therapy (RT) was administered to a total dose of 50-70 Gy/25-35 fractions (median 60 Gy/30 fractions) with elective nodal irradiation of 40 Gy/20 fractions. The standard chemotherapy regimen consisted of two cycles of CDDP 70mg/m2 as the intravenous infusion and 5FU 700mg/m2 as the continuous infusion on 4 days of each cycle during RT. The median follow-up for survivors was 27 months (range, 5-67 months). Planned RT was accomplished in 49 elderly (96%) and 81 nonelderly (98%) patients (p = 0.62). One nonelderly patient discontinued RT because of bleeding from tumor. Two elderly and 1 nonelderly patients interrupted RT more than one week because of toxicities. Only 26 patients (51%) was able to complete standard chemo regimen in the elderly, whereas 65 patients (78%) completed standard chemo regimen in the nonelderly (p<0.01). Complete response (CR) rate was 55% in the elderly and 57% in the nonelderly. The 2-year overall survival rate (OS) was 61% in the elderly and 67% in the nonelderly. There was no significant difference in CR rate and OS according to age and chemotherapeutic dose. In the patients with stage II/III except T4, there was also no significant difference in CR rate and OS between the elderly and nonelderly. Acute toxicities ≥grade 3 were observed 65% in the elderly and 61% in the nonelderly (p = 0.70). Most common ≥grade 3 toxicity was hematologic toxicity in both groups. Grade 5 toxicity was observed in two elderly patients who completed standard treatment regimen. Almost all elderly patients were able to complete planned RT. However, standard CDDP/5FU regimen was achieved in only half of the elderly patients. Chemotherapeutic dose did not affect CR rate and OS. These results suggest further investigation is required for optimal chemotherapy regimen in elderly patients." @default.
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• W2045687629 date "2014-09-01" @default.
• W2045687629 modified "2023-10-14" @default.
• W2045687629 title "Tolerability and Outcome of Definitive Chemoradiation Therapy for Elderly Patients With Esophageal Cancer" @default.
• W2045687629 doi "https://doi.org/10.1016/j.ijrobp.2014.05.1130" @default.
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