Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045688305> ?p ?o ?g. }
- W2045688305 endingPage "1822" @default.
- W2045688305 startingPage "1818" @default.
- W2045688305 abstract "The 95 % ethanol extract of Gelsemium sempervirens showed inhibitory activity against human DNA topoisomerase I (Topo I). Phytochemical investigations of this active extract resulted in the isolation and identification of three new steroids (1 – 3), together with eight known compounds 12β-hydroxy-5α-pregn-16-ene-3,20-dione (4), gelsemine (5), sempervirine (6), scopoletin (7), 7-O-β-D-glucopyranosylscopoletin (8), 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranosylscopoletin (9), uvaol (10), and 2-(4-hydroxyphenyl)ethyl heptadecanoate (11). The structures of the new steroids were determined by extensive NMR and HR-ESI-MS analyses as 21-hydroxy-5α-pregn-16-ene-3,20-dione (1), 3-oxoandrosta-16-ene-17-carboxylic acid (2), and 3-oxoandrosta-4,16-diene-17-carboxylic acid (3). This study suggests that sempervirine (6) intercalates to DNA and also inhibits Topo I through modulating the enzyme activity with an IC50 of 54.5 ± 15.9 μM." @default.
- W2045688305 created "2016-06-24" @default.
- W2045688305 creator A5009710165 @default.
- W2045688305 creator A5013736647 @default.
- W2045688305 creator A5061888573 @default.
- W2045688305 creator A5086232250 @default.
- W2045688305 date "2008-11-17" @default.
- W2045688305 modified "2023-10-08" @default.
- W2045688305 title "Steroids, Alkaloids, and Coumarins from<i>Gelsemium sempervirens</i>" @default.
- W2045688305 cites W1534697474 @default.
- W2045688305 cites W1536538430 @default.
- W2045688305 cites W1971391615 @default.
- W2045688305 cites W1971392271 @default.
- W2045688305 cites W1979012286 @default.
- W2045688305 cites W1983043493 @default.
- W2045688305 cites W1992341844 @default.
- W2045688305 cites W1998035198 @default.
- W2045688305 cites W2016459192 @default.
- W2045688305 cites W2025585137 @default.
- W2045688305 cites W2026528166 @default.
- W2045688305 cites W2031124598 @default.
- W2045688305 cites W2035307486 @default.
- W2045688305 cites W2045046821 @default.
- W2045688305 cites W2048205777 @default.
- W2045688305 cites W2072492794 @default.
- W2045688305 cites W2077846416 @default.
- W2045688305 cites W2078597534 @default.
- W2045688305 cites W2095408194 @default.
- W2045688305 cites W2099896847 @default.
- W2045688305 cites W2133718696 @default.
- W2045688305 cites W2151507383 @default.
- W2045688305 cites W2319366387 @default.
- W2045688305 cites W2403976255 @default.
- W2045688305 cites W2952451004 @default.
- W2045688305 doi "https://doi.org/10.1055/s-0028-1088327" @default.
- W2045688305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19016214" @default.
- W2045688305 hasPublicationYear "2008" @default.
- W2045688305 type Work @default.
- W2045688305 sameAs 2045688305 @default.
- W2045688305 citedByCount "19" @default.
- W2045688305 countsByYear W20456883052012 @default.
- W2045688305 countsByYear W20456883052013 @default.
- W2045688305 countsByYear W20456883052014 @default.
- W2045688305 countsByYear W20456883052015 @default.
- W2045688305 countsByYear W20456883052016 @default.
- W2045688305 countsByYear W20456883052019 @default.
- W2045688305 countsByYear W20456883052021 @default.
- W2045688305 countsByYear W20456883052023 @default.
- W2045688305 crossrefType "journal-article" @default.
- W2045688305 hasAuthorship W2045688305A5009710165 @default.
- W2045688305 hasAuthorship W2045688305A5013736647 @default.
- W2045688305 hasAuthorship W2045688305A5061888573 @default.
- W2045688305 hasAuthorship W2045688305A5086232250 @default.
- W2045688305 hasConcept C142724271 @default.
- W2045688305 hasConcept C147897179 @default.
- W2045688305 hasConcept C181199279 @default.
- W2045688305 hasConcept C185592680 @default.
- W2045688305 hasConcept C195475562 @default.
- W2045688305 hasConcept C204787440 @default.
- W2045688305 hasConcept C2776211264 @default.
- W2045688305 hasConcept C2779074116 @default.
- W2045688305 hasConcept C2780473948 @default.
- W2045688305 hasConcept C55493867 @default.
- W2045688305 hasConcept C556039675 @default.
- W2045688305 hasConcept C71240020 @default.
- W2045688305 hasConcept C71924100 @default.
- W2045688305 hasConceptScore W2045688305C142724271 @default.
- W2045688305 hasConceptScore W2045688305C147897179 @default.
- W2045688305 hasConceptScore W2045688305C181199279 @default.
- W2045688305 hasConceptScore W2045688305C185592680 @default.
- W2045688305 hasConceptScore W2045688305C195475562 @default.
- W2045688305 hasConceptScore W2045688305C204787440 @default.
- W2045688305 hasConceptScore W2045688305C2776211264 @default.
- W2045688305 hasConceptScore W2045688305C2779074116 @default.
- W2045688305 hasConceptScore W2045688305C2780473948 @default.
- W2045688305 hasConceptScore W2045688305C55493867 @default.
- W2045688305 hasConceptScore W2045688305C556039675 @default.
- W2045688305 hasConceptScore W2045688305C71240020 @default.
- W2045688305 hasConceptScore W2045688305C71924100 @default.
- W2045688305 hasIssue "15" @default.
- W2045688305 hasLocation W20456883051 @default.
- W2045688305 hasLocation W20456883052 @default.
- W2045688305 hasOpenAccess W2045688305 @default.
- W2045688305 hasPrimaryLocation W20456883051 @default.
- W2045688305 hasRelatedWork W1992569490 @default.
- W2045688305 hasRelatedWork W2009499599 @default.
- W2045688305 hasRelatedWork W2021208699 @default.
- W2045688305 hasRelatedWork W2032251647 @default.
- W2045688305 hasRelatedWork W2036649323 @default.
- W2045688305 hasRelatedWork W2062604169 @default.
- W2045688305 hasRelatedWork W2072411104 @default.
- W2045688305 hasRelatedWork W2091498869 @default.
- W2045688305 hasRelatedWork W2099428025 @default.
- W2045688305 hasRelatedWork W3217066818 @default.
- W2045688305 hasVolume "74" @default.
- W2045688305 isParatext "false" @default.
- W2045688305 isRetracted "false" @default.
- W2045688305 magId "2045688305" @default.