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• W2045692145 abstract "Prebiotic chemical reactions would have been greatly aided by a process whereby living materials could have been recycled under conditions of limiting resources. Recombination of RNA fragments is a viable means of recycling but has not been demonstrated. Using systems based on the Azoarcus group I intron ribozyme, computational Monte Carlo studies indicate that a moderate level of recycling activity, spontaneous or catalyzed, leads to the most robust selection scenarios. It is interesting that recycling leads to a threshold effect where a dominant species suddenly jumps to fixation. In conjunction, laboratory studies with the Azoarcus ribozyme corroborate these results, showing that mixtures of scrambled and/or deleteriously mutated molecules can recycle their component fragments to generate fully functional recombinase ribozymes. These studies highlight the importance of recombination and recycling jointly in the advent of living systems." @default.
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• W2045692145 date "2013-02-01" @default.
• W2045692145 modified "2023-10-15" @default.
• W2045692145 title "Recycling of Informational Units Leads to Selection of Replicators in a Prebiotic Soup" @default.
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• W2045692145 doi "https://doi.org/10.1016/j.chembiol.2013.01.007" @default.
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