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- W2045692389 abstract "Background: Genetic polymorphism (PI A2) of the platelet GPllla protein has been associated with increased thrombosis and myocardial infarctnon compared to the Al Al status; the rare A2A2 status confers the greatest risk, while the AlAZ status confers rather modest risk. The association of PI A2 with adverse events after percutaneous coronary intervention (PCI) is unknown. Patients and Methods: We followed 153 consecutive patients with normal baseline CKMB, who underwent elective PCI for symptomatic coronary artery disease for 1 year. All patients were tested for PI A2 polymorphism. Adverse events were recorded and adjudicated by an independent committee blinded to the polymorphism status. All patients received ASA and Clopidogrel for one month post PCI. Results: The normal (AIAI) and heterozygous (Al AZ) variants were found in 106 (70.6%) and 45 (29.4%) of the patients respectively; the homozygous variant was not detected in this population. Baseline patient and lesion characteristics, as well as platelet aggregation assay, maximum activated cloting time value and use of GP Ilb/llla blockers were similar between the 2 groups. There were no differences in outcome between groups (Table). Conclusions: Heterozygous genetic polymorphism PI Al A2 was found in approximately one third of patients undergoing elective PCI and it was not associated with any increase in early or late adverse outcomes after PCI compared to the normal homozygous PI AIAI status." @default.
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- W2045692389 date "2003-03-01" @default.
- W2045692389 modified "2023-09-24" @default.
- W2045692389 title "Does genetic polymorphism for platelet glycoprotein illa impact early and long-term outcomes after elective percutaneous coronary interventions?" @default.
- W2045692389 doi "https://doi.org/10.1016/s0735-1097(03)80048-7" @default.
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