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• W2045694972 startingPage "742" @default.
• W2045694972 abstract "An in vitro screening method for selective acetylcholinesterase (AChE) inhibitors was established. Inhibitory activity of AChE and butyrylcholinesterase (BuChE) was measured and the culture broths of microorganisms that showed selective inhibition against AChE were characterized.By using this method, a strain producing the novel and selective inhibitors of AChE, arisugacins A and B, was picked out among over seven thousand microorganisms tested. Arisugacins were obtained as white powders from the culture broth together with three known compounds, territrems B and C and cyclopenin that also showed selective inhibition against AChE. Arisugacins and territrems are members of the meroterpenoid compounds. They showed potent inhibitory activities against AChE with IC50 values in range of 1.0-25.8nM. Furthermore, they showed greater than 2, 000-fold more potent inhibition against AChE than BuChE." @default.
• W2045694972 created "2016-06-24" @default.
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• W2045694972 date "1996-01-01" @default.
• W2045694972 modified "2023-10-18" @default.
• W2045694972 title "Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. FO-4259. I. Screening, Taxonomy, Fermentation, Isolation and Biological Activity." @default.
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• W2045694972 doi "https://doi.org/10.7164/antibiotics.49.742" @default.
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