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- W2045697933 abstract "Norbormide is a vasoconstrictor of rat peripheral arteries and a relaxant in rat aorta. To characterise norbormide actions within the rat vascular tree we have investigated its effects on the contractile function of rings from several arteries and veins. A maximal norbormide concentration (50 μM) failed to contract thoracic aorta and carotid artery, whereas in pulmonary artery, abdominal aorta, iliac, caudal, and femoral arteries it induced a contractile effect that was respectively 4.8 ± 0.6, 18.4 ± 1.5, 39 ± 5, 144 ± 7, and 260 ± 22% of that induced by 90 mM KCl. In pulmonary, carotid, and iliac arteries, and in thoracic and abdominal aorta, 50 μM norbormide inhibited KCl-induced responses. Norbormide (50 μM) contracted all veins investigated. The effect, expressed as % of KCl-induced contraction, was 121 ± 25, 154 ± 14.5, 154 ± 18.2, 203 ± 19, and 267 ± 33 for pulmonary vein, thoracic and abdominal vena cava, iliac and jugular veins, respectively. In jugular vein, as previously shown in rat caudal artery, norbormide contraction was abolished in Ca 2+ -free medium, was unaffected by the Ca 2+ channel blocker nifedipine, and was relaxed by SK&F 96365, a blocker of store-operated Ca 2+ channels. In conclusion: i) rat veins represent the main target for contractile norbormide action; ii) in both artery and veins norbormide contractions are generally inversely related to the calibre of the vessel; iii) norbormide-induced contraction is mediated by the same mechanism/s in arteries and veins; iiii) in norbormide-contracted arteries the drug activates both contractile and relaxing mechanisms." @default.
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- W2045697933 date "2004-09-01" @default.
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- W2045697933 title "Distribution of the vasoconstrictor and vasorelaxant effects of norbormide along the vascular tree of the rat" @default.
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- W2045697933 doi "https://doi.org/10.1016/j.lfs.2004.04.022" @default.
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