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- W2045698173 abstract "The vasoactive peptide endothelin-1 (ET-1) was found to bind to a single class of binding sites in chick embryonic sensory ganglia with a Kd of 67 +/- 5 pM. Treatment of ganglia explants with 100 pM ET-1 did not affect neuronal development, but when added together with 12-O-tetradecanoylphorbol-13-acetate (TPA) a synergistic stimulation of neurite outgrowth was observed. In contrast, 10 nM ET-1 inhibited TPA-induced neurite outgrowth. Both the stimulatory and inhibitory effects were not blocked by nifedipine, a Ca2+ channel blocker. These results suggest that ET-1 can modulate the process of neurite outgrowth and its effects are not dependent on voltage-gated Ca2+ channels." @default.
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- W2045698173 date "1992-03-01" @default.
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- W2045698173 title "Dual effects of endothelin-1 on neurite outgrowth induced by 12-O-tetradecanoylphorbol-13-acetate" @default.
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- W2045698173 doi "https://doi.org/10.1016/0304-3940(92)90053-a" @default.
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