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• W2045702960 abstract "We report the case of an elderly lady presenting with dizziness, a head injury resulting from a fall and bradycardia. Propafenone 150 mg t.i.d. had been prescribed for atrial fibrillation with tachyarrhythmia, induced by hyperthyroidism, 18 months earlier. A toxic concentration of parent propafenone, and no 5-hydroxy metabolite, was detected in a plasma sample. Symptoms disappeared after the discontinuation of propafenone. The poor metaboliser (PM) phenotype of sparteine/debrisoquine was assumed and subsequently confirmed by phenotyping (sparteine test) and genotyping (allele-specific polymerase chain reaction). The PM phenotype is common in European populations, with a prevalence of about 7%. If drugs with narrow therapeutic ranges undergo genetically polymorphic metabolism, toxicity may arise even with recommended doses. Individualization of doses is required to avoid adverse effects." @default.
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• W2045702960 date "1995-11-01" @default.
• W2045702960 modified "2023-10-17" @default.
• W2045702960 title "Propafenone in a usual dose produces severe side-effects: the impact of genetically determined metabolic status on drug therapy" @default.
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• W2045702960 doi "https://doi.org/10.1111/j.1365-2796.1995.tb01225.x" @default.
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