FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045703559> ?p ?o ?g. }

• W2045703559 endingPage "177" @default.
• W2045703559 startingPage "164" @default.
• W2045703559 abstract "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), acting through the aromatic hydrocarbon receptor (AhR), elicits numerous toxicological effects, including immunosuppression. Previous work from our laboratory has suggested that TCDD exposure in mice is associated with altered lymphopoietic development, in particular altered B-cell phenotype in the bone marrow. It remains to be determined which specific hematopoietic populations or subpopulations within the marrow cavity are directly targeted by TCDD. To examine the effects of TCDD on developing B cells in vitro, a stromal coculture model was used. Primary bone marrow cells from male, 6- to 7-week-old C57Bl/6 mice were cocultured separately on two AhR-containing stromal cell lines (M2-10B4 and S17) that support B-cell development in the presence of IL-7. The cocultures were treated with 0 to 10 nM TCDD. Shifts in phenotype were quantified by cell surface marker staining and flow cytometry. Four populations in the maturing B cell (very early pre-pro-B, pre-pro-B, pro-B, and pre-B) were defined for quantification. The results show that the only statistically significant effect of TCDD was within the pre-pro-B population in cultures with the S17 stromal cell line. The increase in number of cells with this phenotype was seen in cultures with both wild-type and AhR-/- primary bone marrow cells. These results suggest that the maturing B220+ B cell is not the direct target for TCDD-induced bone marrow B-cell alterations." @default.
• W2045703559 created "2016-06-24" @default.
• W2045703559 creator A5016601438 @default.
• W2045703559 creator A5025119335 @default.
• W2045703559 creator A5040528387 @default.
• W2045703559 creator A5058861443 @default.
• W2045703559 date "2002-05-01" @default.
• W2045703559 modified "2023-10-10" @default.
• W2045703559 title "2,3,7,8-Tetrachlorodibenzo-p-dioxin Does Not Directly Alter the Phenotype of Maturing B Cells in a Murine Coculture System" @default.
• W2045703559 cites W1482479272 @default.
• W2045703559 cites W1507248727 @default.
• W2045703559 cites W1580335186 @default.
• W2045703559 cites W1580591725 @default.
• W2045703559 cites W1607369399 @default.
• W2045703559 cites W1640887277 @default.
• W2045703559 cites W1758583904 @default.
• W2045703559 cites W1937346665 @default.
• W2045703559 cites W1969155375 @default.
• W2045703559 cites W1969656285 @default.
• W2045703559 cites W1971213881 @default.
• W2045703559 cites W1980509634 @default.
• W2045703559 cites W1988333201 @default.
• W2045703559 cites W1998153902 @default.
• W2045703559 cites W1998311027 @default.
• W2045703559 cites W2001141951 @default.
• W2045703559 cites W2012174763 @default.
• W2045703559 cites W2036340292 @default.
• W2045703559 cites W2046728209 @default.
• W2045703559 cites W2058501235 @default.
• W2045703559 cites W2069501059 @default.
• W2045703559 cites W2069615428 @default.
• W2045703559 cites W2077461932 @default.
• W2045703559 cites W2077930477 @default.
• W2045703559 cites W2090939833 @default.
• W2045703559 cites W2096001385 @default.
• W2045703559 cites W2098758154 @default.
• W2045703559 cites W2100535878 @default.
• W2045703559 cites W2103364061 @default.
• W2045703559 cites W2117455815 @default.
• W2045703559 cites W2125522176 @default.
• W2045703559 cites W2136523893 @default.
• W2045703559 cites W2152837634 @default.
• W2045703559 cites W2162067613 @default.
• W2045703559 cites W2169799836 @default.
• W2045703559 cites W2177231732 @default.
• W2045703559 cites W2343968721 @default.
• W2045703559 cites W43065862 @default.
• W2045703559 cites W4313347829 @default.
• W2045703559 doi "https://doi.org/10.1006/taap.2002.9396" @default.
• W2045703559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12009856" @default.
• W2045703559 hasPublicationYear "2002" @default.
• W2045703559 type Work @default.
• W2045703559 sameAs 2045703559 @default.
• W2045703559 citedByCount "12" @default.
• W2045703559 countsByYear W20457035592017 @default.
• W2045703559 countsByYear W20457035592018 @default.
• W2045703559 countsByYear W20457035592021 @default.
• W2045703559 crossrefType "journal-article" @default.
• W2045703559 hasAuthorship W2045703559A5016601438 @default.
• W2045703559 hasAuthorship W2045703559A5025119335 @default.
• W2045703559 hasAuthorship W2045703559A5040528387 @default.
• W2045703559 hasAuthorship W2045703559A5058861443 @default.
• W2045703559 hasConcept C104317684 @default.
• W2045703559 hasConcept C109159458 @default.
• W2045703559 hasConcept C126322002 @default.
• W2045703559 hasConcept C127716648 @default.
• W2045703559 hasConcept C134018914 @default.
• W2045703559 hasConcept C1491633281 @default.
• W2045703559 hasConcept C153911025 @default.
• W2045703559 hasConcept C159654299 @default.
• W2045703559 hasConcept C16930146 @default.
• W2045703559 hasConcept C185592680 @default.
• W2045703559 hasConcept C203014093 @default.
• W2045703559 hasConcept C2778453870 @default.
• W2045703559 hasConcept C2780007613 @default.
• W2045703559 hasConcept C28328180 @default.
• W2045703559 hasConcept C2908647359 @default.
• W2045703559 hasConcept C502942594 @default.
• W2045703559 hasConcept C54355233 @default.
• W2045703559 hasConcept C553184892 @default.
• W2045703559 hasConcept C55493867 @default.
• W2045703559 hasConcept C71924100 @default.
• W2045703559 hasConcept C81885089 @default.
• W2045703559 hasConcept C86803240 @default.
• W2045703559 hasConcept C95444343 @default.
• W2045703559 hasConcept C99454951 @default.
• W2045703559 hasConceptScore W2045703559C104317684 @default.
• W2045703559 hasConceptScore W2045703559C109159458 @default.
• W2045703559 hasConceptScore W2045703559C126322002 @default.
• W2045703559 hasConceptScore W2045703559C127716648 @default.
• W2045703559 hasConceptScore W2045703559C134018914 @default.
• W2045703559 hasConceptScore W2045703559C1491633281 @default.
• W2045703559 hasConceptScore W2045703559C153911025 @default.
• W2045703559 hasConceptScore W2045703559C159654299 @default.
• W2045703559 hasConceptScore W2045703559C16930146 @default.
• W2045703559 hasConceptScore W2045703559C185592680 @default.
• W2045703559 hasConceptScore W2045703559C203014093 @default.
• W2045703559 hasConceptScore W2045703559C2778453870 @default.

• next